1089671-20-4

Upstream product

• 937-30-4 4-ethylacetophenone 
• 80154-34-3 formaldehydephenlyl-O-β-D-pyranosyl alloside 

Downstream Products

• 1089663-35-3 6H-2-amino-4-(4-ethylphenyl)-6-(4-β-D-allopyranosyloxyphenyl)-1,3-thiazine 
• 1191907-68-2 4-(2-amino-6-(4-ethylphenyl)pyrimidin-4-yl)phenyl β-D-allopyranoside 

Relevant academic research and scientific papers

Synthesis and calming activity of 6H-2-amino-4-aryl-6- (4-β-D- allopyranosyloxyphenyl)-1,3-thiazine

E-(4-β-D-Allopyranosyloxyphenyl)-1-(4-substituted phenyl)propenone derivatives (1a-g) have been synthesized by the Claisen-Schmidt condensation of helicid with 4-substituted acetophenone using 10% NaOH aqueous solution as a catalyst. 6H-2-Amino-4-aryl-6-(4-β-D-allopyranosyloxyphenyl)-1,3-thiazine (2a-g) were synthesized by the 1,4-Michael reaction of 1a-g with thiourea. The structures of all the new products were established by 1H NMR, IR, and MS spectroscopy. Compound 2b (200 mg.kg-1) showed better sedative-hypnotic activity, so further modification of helicid should be worthwhile.