108974-41-0Relevant academic research and scientific papers
Cyano-borrowing reaction: Nickel-catalyzed direct conversion of cyanohydrins and aldehydes/ketones to β-cyano ketone
Li, Zhao-Feng,Li, Qian,Ren, Li-Qing,Li, Qing-Hua,Peng, Yun-Gui,Liu, Tang-Lin
, p. 5787 - 5792 (2019/06/17)
A direct nickel-catalyzed, high atom- and step-economical reaction of cyanohydrins with aldehydes or ketones via an unprecedented "cyano-borrowing reaction" has been developed. Cleavage of the C-CN bond of cyanohydrins followed by aldol condensation and conjugate addition of cyanide to α,β-unsaturated ketones proceeded to deliver a range of racemic β-cyano ketones with good to high yields. The practical procedure with the use of a commercial and less-toxic CN source bodes well for wide application of this protocol.
Highly efficient Cs2CO3-catalyzed 1,4-addition of Me3SiCN to enones with water as the additive
Yang, Jingya,Shen, Yongbin,Chen, Fu-Xue
experimental part, p. 1325 - 1333 (2010/07/02)
A facile and efficient 1,4-addition of Me3SiCN to enones has been achieved with perfect regioselectivity using Cs2CO3 as catalyst. Thus, with 0.5 mol% of Cs2CO3 and 4 equivalents of H2O as the additive excellent yields (81-99%) of -cyanoketones are obtained within one to five hours. Both aromatic and aliphatic enones are found suitable substrates for this protocol. Georg Thieme Verlag Stuttgart · New York.
Highly efficient syntheses of β-cyanoketones via conjugate addition of Me3SiCN to aromatic enones
Yang, Jingya,Chen, Fuxue
experimental part, p. 981 - 987 (2010/10/03)
An efficient 1,4-addition of Me3SiCN to aromatic enones has been achieved with excellent yields (91%-99%) using CsF (1 mol%) as the catalyst and H2O (4 equiv.) as the additive in refluxing dioxane within 7 h. The perfect regioselecti
The highly efficient 1,4-addition of TMSCN to aromatic enones catalyzed by CsF with water as the additive
Yang, Jingya,Wang, Yinxian,Wu, Shaoxiang,Chen, Fu-Xue
experimental part, p. 3365 - 3367 (2010/03/03)
An efficient 1,4-addition of TMSCN to aromatic enones has been achieved in excellent yields (91-99%) by CsF (1 mol%) as the catalyst and H2O (4 equiv) as the additive in refluxing dioxane within 2-7 hours. Georg Thieme Verlag Stuttgart - New Yo
