108976-72-3Relevant academic research and scientific papers
Photochemical Reaction of Ethyl 3-Oxo-2,4-diphenylbutanoate
Yoshioka, Michikazu,Osawa, Haruhiko,Fukuzawa, Shinji
, p. 877 - 879 (1982)
Irradiation of ethyl 3-oxo-2,4-diphenylbutanoate in hexane gave the products formed by recombination of the radicals (Ph-CH2 and/or Ph-CH-CO2Et)resulting from decarbonylation, together with small amounts of 1,2-diphenylethanol and ethyl α-hydroxyphenylacetate, whereas in benzene no 1,2-diphenylethanol was found.Under oxygen an increased amount of ethyl α-hydroxyphenylacetate and no radical recombination products were observed.
Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis
Chen, Lin-Hai,Fang, You-Chen,Nan, Fa-Jun,Xiao, Yu-Feng,Xie, Xin,Zhang, Qing
, p. 3991 - 4006 (2022/03/14)
GPR84 is a proinflammatory G protein-coupled receptor associated with several inflammatory and fibrotic diseases. GPR84 antagonists have been evaluated in clinical trials to treat ulcerative colitis, idiopathic pulmonary fibrosis, and nonalcoholic steatohepatitis. However, the variety of potent and selective GPR84 antagonists is still limited. Through high-throughput screening, a novel phosphodiester compound hit 1 was identified as a GPR84 antagonist. The subsequent structural optimization led to the identification of compound 33 with improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. In a DSS-induced mouse model of ulcerative colitis, compound 33 significantly alleviated colitis symptoms and reduced the disease activity index score at oral doses of 25 mg/kg qd, with an efficacy similar to that of positive control 5-aminosalicylic acid (200 mg/kg, qd, po), suggesting that compound 33 is a promising candidate for further drug development.
Flow-vacuum pyrolysis of polycyclic compounds. 27.1 pyrolysis of 8,9-dihydro-14h-tetrazolo[1,5a]dibenzo[c,f]azonine and 6,7,8,9-tetrahydro- tetrazolo[1,5a]benzo[c]azocine
Popescu, Angela,Andrei, Elena,Istrati, Daniela,Draghici, Constantin,Ciuculescu, Crinu
scheme or table, p. 875 - 881 (2011/06/21)
The flow-vacuum pyrolysis (FVP) of 8,9-dihydro-14H-tetrazolo[1,5a] dibenzo[c,f]azonine (13) and 6,7,8,9-tetrahydrotetrazolo[ 1,5-a]benzo[c]azocine (14) in quartz tube, inert atmosphere, between 300-550°C in vacuum was investigated using GC/MS. The corresp
