108997-30-4

Usage

Uses

Used in Pharmaceutical Applications:
Curcumin is utilized as a therapeutic agent for its anti-inflammatory and antioxidant properties, making it a potential treatment for conditions such as arthritis, diabetes, and neurodegenerative disorders. Its anti-cancer properties are also being explored for its potential to combat various types of cancer.
Used in Heart Health Applications:
Curcumin is used as a supplement to promote heart health due to its ability to improve cardiovascular function and reduce the risk of heart-related diseases.
Used in Cognitive Function Applications:
It is also recognized for its potential to improve cognitive function, making it a candidate for use in treatments for neurodegenerative conditions that affect cognitive abilities.
Used in Food Industry:
In the food industry, curcumin is used as a natural preservative and coloring agent, capitalizing on its ability to enhance the visual appeal and shelf life of various food products.
Overall, (E)-1,3-bis(4-hydroxyphenyl)prop-2-en-1-one, or curcumin, is a versatile compound with a wide range of applications across different industries, primarily due to its health-promoting and medicinal properties.

InChI:InChI=1/C15H12O3/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,16-17H/b10-3+

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 99-93-4 4-Hydroxyacetophenone 
• 41564-67-4 (E)-1,3-bis(4-methoxyphenyl)-2-propene-1-one 
• 121-71-1 3-Hydroxyacetophenone 
• 109555-07-9 4,4'-diacetoxychalcone 
• 457629-77-5 4,4'-bis(tetrahydropyran-2-yloxy)chalcone 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 2373-89-9 4,4'-dimethoxychalcone 
• 16162-69-9 1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethanone 
• 468060-21-1 (E)-1,3-bis(4-[tetrahydro-2H-pyran-2-yloxy]phenyl)prop-2-en-1-one 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 

Downstream Products

• 112163-64-1 4,4'-dinonyloxychalcone 
• 1222313-22-5 4-(4'-hydroxyphenyl)-2-(4-hydroxyphenyl)-2,3-dihydro-1,5-benzoxazepine 
• 1222313-17-8 4-(4'-hydroxyphenyl)-2-(4-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepine 
• 175520-27-1 (E)-4,4'-(3-ethenyl-1-propene-1,3-diyl)bisphenol 
• 1428324-88-2 1-(3,5-bis(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one 

Relevant academic research and scientific papers

Liquid crystalline epoxy thermosets

Rigid rod epoxy compounds can be cured in liquid crystalline structure. The so obtained networks exhibit better mechanical properties with respect to the isotropic ones. The mesogenic character of the epoxy compounds appears more crucial than the molecular geometry of the curing agent in developing liquid crystallinity. The curing temperature plays an important role in affecting the state of order of the thermosets.

Antibacterial and anti-inflammatory activity of valproic acid-pyrazole conjugates as a potential agent against periodontitis

Periodontitis is a serious global concern. Therefore, in the present study, we intend to synthesize novel valproic-acid pyrazole conjugates as a novel agent against periodontitis. The molecules were developed in a facile synthetic route and obtained in ex

4,4'-DIHYDROXYCHALCONE FROM THE HEARTWOOD OF CHAMAECYPARIS OBTUSA

A new chalcone, 4,4'-dihydroxychalcone was isolated from the heartwood of Chamaecyparis obtusa.The structure was elucidated by direct comparison with a synthetic sample.

Photo-sensitive benzoxazine II: Chalcone-containing benzoxazine and its photo and thermal-cured thermoset

A chalcone-containing benzoxazine (BHP-a) was synthesized from a chalcone-containing bisphenol: 1,3-bis(4-hydroxyphenyl) propanone (BHP), aniline and paraformaldehyde in a co-solvent of xylene/1-butanol (2/1, V/V). The structure of BHP-a was successfully

A simple and highly efficient method for the synthesis of chalcones by using borontrifluoride-etherate

Chalcones are secondary metabolites of terrestrial plants, precursors for the biosynthesis of flavonoids and exhibit various biological activities. Condensation of substituted acetophenones (2a-12a) with various aromatic aldehydes (1b-7b) in the presence of BF3-Et2O at room temperature gave chalcones in 75-96% yield.

Method for efficiently synthesizing 1, 3-bis (4-hydroxyphenyl)-2-propylene-1-ketone

The invention discloses a method for efficiently synthesizing 1, 3-bis (4-hydroxyphenyl)-2-propene-1-ketone, and belongs to the field of organic chemical synthesis. According to the method, a Claisen-Schmidt reaction is carried out, p-hydroxybenzaldehyde

Discovery of isoliquiritigenin analogues that reverse acute hepatitis by inhibiting macrophage polarization

Screening a natural product library of 850 compounds yield isoliquiritigenin as an effective anti-inflammatory agent by inhibiting the production of pro-inflammatory NO induced by Pam3CSK4, while its activity accompanied by toxicity. Further studies obtained the optimized isoliquiritigenin derivative SMU-B14, which can inhibit Pam3CSK4 triggered toll-like receptor 2 (TLR2) signaling with low toxicity and high potency. Preliminary mechanism studies indicated that SMU-B14 worked through TLR2/MyD88, phosphorylation of IKKα/β, leading to the reduce degradation of NF-κB related IKBα and p65 complex, then inhibited the production of inflammatory cytokines, such as TNF-α, IL-6, IL-1β both in human and murine cell lines. Subsequent polarization experiments showed SMU-B14 significant reversed the polarization of M1 phenotype primary macrophage activated by Pam3CSK4 in vitro, and reduced the infiltration of neutrophil and polarization of M1-type macrophage, decreased serum alanine transaminase (ALT), as a result protected liver from being injured in vivo. In summary, we obtained an optimized lead compound SMU-B14 and found it functionally blocked TLR2/MyD88/NF-κB signaling pathway to down-regulate the production of inflammatory cytokines resulted significant liver protection property.

Biocatalytic green alternative to existing hazardous reaction media: Synthesis of chalcone and flavone derivatives via the Claisen-Schmidt reaction at room temperature

Owing to the increasing amount of waste materials around the globe, the conversion of waste or secondary by-products to value-added products for various applications has gained significant interest. Herein, two novel agro-food waste products, Musa sp. 'Malbhog' peel ash (MMPA) and Musa Champa Hort. ex Hook. F. peel ash (MCPA) are used as catalysts to promote an inexpensive, efficient and eco-friendly carbon-carbon bond forming crossed aldol reaction at room temperature in solvent free conditions. Furthermore, the resulting products were subjected to reactions with these promoters in an oxygen atmosphere and led to the formation of novel flavone derivatives. Moreover, the used catalysts were properly characterized using different sophisticated analytical techniques such as Fourier-transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), Brunauer-Emmett-Teller analysis (BET), Raman spectroscopy, scanning electron microscopy energy dispersive X-ray spectroscopy (SEM-EDS), transition electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA) along with element detection using atomic absorption spectroscopy and ion chromatographic methods. These two approaches are metal free, as well as being devoid of any extra additives, co-catalysts, harsh conditions, the use of column chromatography for purification and result in a higher yield of the product within a short space of time. The catalytic abilities of the promoter were also examined to synthesize important bioactive molecules such as butein and apigenin at room temperature. With gram scale synthesis of the chalcone derivatives, the used catalysts (MMPA and MCPA) were further reused for five cycles and did not demonstrate any loss in catalytic activity.

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia

Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.

Crosslinking Monomers With at Least One Sulfur Atom

The invention relates to a cross-linking monomer with at least one sulfur atom, representable by a structure of formula (I) wherein the symbols have the following meaning: L1 is a linear, branched or cyclic, saturated or unsaturated, aliphatic