109036-15-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(o-Chloro-α-phenylbenzyl)piperazine is used as a potential therapeutic agent for the treatment of various disorders, particularly neurological conditions. Its development is based on the structure of the N-type calcium channel blocker NP118809, suggesting that it may have similar or improved pharmacological properties.
Used in Drug Discovery and Development:
1-(o-Chloro-α-phenylbenzyl)piperazine serves as a valuable compound in drug discovery and development efforts. Researchers can use its unique structure as a starting point for designing new drugs with improved efficacy, safety, and selectivity. Its potential as a calcium channel blocker may also lead to the development of novel treatments for various diseases, including neurological disorders and pain management.

Upstream product

• 110-85-0 piperazine 
• 56961-47-8 2-chloro-benzhydryl chloride 

Downstream Products

• 661453-53-8 C₃₂H₃₁ClN₂O 
• 866562-72-3 2-{4-[(2-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-N,N-diphenyl-acetamide 
• 878162-12-0 4-[(2-chloro-phenyl)-phenyl-methyl]-piperazine-1-carboxylic acid benzhydryl-amide 
• 866562-53-0 1-{4-[(2-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylamino-ethanone 

Relevant academic research and scientific papers

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.

Process for producing piperazinesulfonamide derivatives and salts thereof

A process for advantageously preparing a piperazinesulfonamide derivative represented by the general formula (III): wherein R1 is hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group or amino group; R2 is a phenyl group which may have as substituents on its phenyl ring 1 to 3 groups selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group and amino group, 2-pyridyl group, 3-pyridyl group or 4-pyridyl group; each of R3 and R4 is independently hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, a hydroxyalkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a phenyl group which may be substituted; and Y is an alkylene group having 1 to 12 carbon atoms, and a salt thereof.