109042-93-5Relevant academic research and scientific papers
IBX-mediated α-hydroxylation of α-alkynyl carbonyl systems. A convenient method for the synthesis of tertiary alcohols
Kirsch, Stefan F.
, p. 10210 - 10212 (2005)
IBX (o-iodoxybenzoic acid) is an excellent reagent for the α-hydroxylation of α-alkynyl carbonyl compounds without giving dehydrogenation products. The convenient procedure proves to be useful for the construction of a variety of tertiary alcohols (55-91%
Pt-catalyzed cyclization/migration of propargylic alcohols for the synthesis of 3(2H)-furanones, pyrrolones, indolizines, and indolizinones
Bunnelle, Eric M.,Smith, Cameron R.,Lee, Sharon K.,Singaram, Surendra W.,Rhodes, Allison J.,Sarpong, Richmond
, p. 7008 - 7014 (2008/09/21)
Several heterocycles such as furanones, pyrrolones, and indolizines, which are of pharmacological importance, are easily accessed via the Pt(II)-catalyzed heterocyclization/1,2-migration of propargylic ketols or hydroxy imine derivatives. This method sidesteps the challenges of traditional heteroaromatic oxygenation strategies such as regioselectivity and functional group tolerance in the syntheses of these heterocycles.
Synthesis of heterocyclic systems by transition-metal-catalyzed cyclization-migration reactions - A diversity-oriented strategy for the construction of spirocyclic 3(2H)-furanones and 3-pyrrolones
Binder, Joerg T.,Crone, Benedikt,Kirsch, Stefan F.,Liebert, Clemence,Menz, Helge
, p. 1636 - 1647 (2008/02/06)
Two platinum(II)-catalyzed heterocyclization-migration reactions that provide five-membered heterocycle products are described. With 5 mol-% of PtCl2 as a catalyst, 2-alkynyl-2-hydroxy carbonyl compounds 1 are converted into 3(2H)-furanones 2 a
