109062-95-5

Upstream product

• 106-99-0 buta-1,3-diene 
• 34212-60-7 di-<(1R,2S,5R)-(-)-menthyl>maleate 
• 2216-51-5 (-)-menthol 
• 34675-24-6 di-L-menthyl fumarate 
• 120143-40-0 (2Z,1'S,2'R,5'S)-but-2-enedioic acid bis(2'-isopropyl-5'methyl-cyclohexyl) ester 
• 15356-60-2 (1S,2R,5S)-(+)-menthol 
• 86287-64-1 (2E,1'S,2'R,5'S)-but-2-enedioic acid bis(2'-isopropyl-5'methyl-cyclohexyl) ester 

Downstream Products

• 121944-09-0 (1S,2R)-1-(4,4-Dimethyl-pent-2-ynoyl)-cyclohex-4-ene-1,2-dicarboxylic acid bis-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 
• 479549-19-4 (1R,2R,4R,5R,1'S,2'R,5'S)-4-hydroxy-5-phenylselanyl-cyclohexane-1,2-dicarboxylic acid bis(2'-isopropyl-5'-methyl-cyclohexyl) ester 
• 956006-34-1 (1S,3R,4R,6R)-3-((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) 4-((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) 7-oxabicyclo[4.1.0]heptane-3,4-dicarboxylate 
• 15679-27-3 (4S,5S)-4,5-bis(hydroxymethyl)cyclohexene 
• 246518-22-9 (1S,3S,4S)-3-(benzyloxymethyl)-4-(hydroxymethyl)cyclopentanol 
• 246518-21-8 (3S,4S)-3-(benzyloxymethyl)-4-(hydroxymethyl)cyclopentanone 

Relevant academic research and scientific papers

ADENYLYL CYCLASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF

The present invention relates to novel adenine based inhibitors of adenylyl cyclase of the formula: wherein X, L, R1, R2, R5 are those defined herein. Compounds of the present invention are useful to treat cardiovascular diseases. The present invention also relates to a method of preventing heart failure by administering an effective amount of compound according to the invention following vascular injury and reperfusion therapy.

Conformative coupling of two conformational molecular switches

Passing on information. Two conformational switches, decalin units, were coupled to a 14-membered bislactam ring (see formula, TBDPS=tert-butyldiphenylsilyl). Removal of a bisacetal clamp on the left side of the molecule resulted in a double ring-flip of

Total synthesis of the polyenoyltetramic acid polycephalin C

The total synthesis of the polyenoyltetramic acid polycephalin C is described. Key steps of the synthesis include a double Swern oxidation, double Takai reaction and a double Stille reaction. In addition, the absolute stereochemistry of the ring junction

Total synthesis of polycephalin C and determination of the absolute configurations at the 3′′,4′′ ring junction

Only through total synthesis could the absolute configuration of the 3′′R,4′′R ring junction of the polyenoltetramic acid polycephalin C (1) be unambiguously established. Key features of the synthesis include a double Swern oxidation, double Stille coupli

Synthesis and biological evaluation of a monocyclic, fully functional analogue of compactin

Compound 8, a monocyclic analogue of compactin, has been prepared and its efficacy as an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGR) evaluated. The synthesis (Schemes I and II) requires seven steps starting with di-(-)-menthyl fumar

ASYMMETRIC DIELS-ALDER REACTION. COOPERATIVE BLOCKING EFFECT IN ORGANIC SYNTHESIS

Remarkably high diastereoselectivity is observed in the organoaluminium catalyzed asymmetric Diels-Alder reaction of (-)-dimenthyl fumarate.