1090904-00-9Relevant articles and documents
Discovery of potent, selective chymase inhibitors via fragment linking strategies
Taylor, Steven J.,Padyana, Anil K.,Abeywardane, Asitha,Liang, Shuang,Hao, Ming-Hong,De Lombaert, Stéphane,Proudfoot, John,Farmer, Bennett S.,Li, Xiang,Collins, Brandon,Martin, Leslie,Albaugh, Daniel R.,Hill-Drzewi, Melissa,Pullen, Steven S.,Takahashi, Hidenori
, p. 4465 - 4481 (2013/07/19)
Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent, selective chymase inhibitors, developed using fragment-based, structure-guided linking and optimizati