1091-89-0

Basic information

• Product Name: estr-5⁽¹⁰⁾-ene-3,6,17-trione
• CAS NO: 1091-89-0
• Molecular Weight: 286.371
• Mol File: 1091-89-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: estr-5⁽¹⁰⁾-ene-3,6,17-trione(CAS DataBase Reference)
• NIST Chemistry Reference: estr-5⁽¹⁰⁾-ene-3,6,17-trione(1091-89-0)
• EPA Substance Registry System: estr-5⁽¹⁰⁾-ene-3,6,17-trione(1091-89-0)

Safety Data

• Hazardous Substances Data: 1091-89-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 100-53-8 phenylmethanethiol 

Downstream Products

• 1476-34-2 6-oxoestrone 

Relevant articles and documents

C(10)-C(19) bond cleavage reaction of 19-oxygenated androst-4-ene-3,6-dione steroids under various conditions

C(10)-C(19) bond cleavage reaction of 19-hydroxy- and 19-oxoandrost-4-ene- 3,6,17-triones (5, 6) was explored under various conditions. Treatment of steroids 5 and 6 with KOH in MeOH gave the A-ring aromatized product 6-oxoestrone (11) in a fair yield, respectively, in contrast, the treatment with a weak base yielded 4-methyl steroid 17 (20%) in the case of 19-alcohol 5 or 19-nor- Δ5(10)-steroid 9 (12-67%) along with compound 11 (6-27%) in the case of 19-aldehyde 6. Reaction of compound 6 with HCl in MeOH produced 3-methyl ethers of 6-oxoestrone and Δ6-estrone, compounds 12 and 14 (ca. 20% each). Thus, 6-oxosteroids 5 and 6 showed unique C(10)-C(19) bond cleavage reactions with a base or acid.