109113-41-9

Upstream product

• 271-34-1 5-azaindole 
• 108-24-7 acetic anhydride 
• 109113-39-5 1-Benzenesulfonyl-1H-pyrrolo<3,2-c>pyridine 
• 148760-46-7 3-(4-Morpholinovinylene)-4-nitropyridine 1-oxide 
• 123367-22-6 (E)-N,N-dimethyl-2-(4-nitro-1-oxidopyridin-3-yl)ethenamine 
• 148760-47-8 3-Dimethylaminovinylene-4-nitropyridine 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 1678-53-1 4-nitro-3-methylpyridine 

Relevant academic research and scientific papers

1H-pyrrolo [3,2-c]pyrrolidines protected in 1-position useful as intermediates

The invention relates to a process for fixing an electrophilic group in the 2-position of 1H-pyrrolo[3,2-c]pyridine N-protected in the 1-position, process which consists in protecting the 1-position in question with a labile protecting group, reacting the compound so obtained with a lithiation agent selected from a lithium amide and an alkyl lithium at a temperature between -80° C. and -20° C. and in the presence of tetramethylethylenediamine to obtain the corresponding 2-lithio derivative and then condensing the metal derivative so obtained at a temperature between -80° C. and room-temperature with a reagent capable of giving rise to an electrophilic group to form N-protected 1H-pyrrolo[3,2-c]pyridine substituted in the 2-position by an electrophilic group.