1091585-30-6Relevant articles and documents
Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution
Hu, Lei,Schaufelberger, Fredrik,Zhang, Yan,Ramstroem, Olof
, p. 10376 - 10378 (2013)
The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.
PROCESS FOR PREPARING SUBSTITUTED 1,3-OXATHIOLANES WITH ANTIVIRAL PROPERTIES
-
, (2008/06/13)
Disclosed are processes for preparing compounds of formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S = O or SO2. The invention also relates to
Enantioselective enzymatic synthesis of the anti-viral agent lamivudine (3TC)
Milton,Brand,Jones,Rayner
, p. 6961 - 6964 (2007/10/02)
A novel enzymatic resolution of α-acetoxysulfides has been used as the key step in the synthesis of the important antiviral nucleoside analogue lamivudine. The synthesis proceeds via a configurationally stable hemithioacetal which cyclises in situ to form the required oxathiolane nucleus, which can then be converted into the target nucleoside in 4 steps.
