1091626-89-9Relevant academic research and scientific papers
Chemoenzymatic synthesis of both enantiomers of 3-hydroxy-2,2- dimethylcyclohexanone
Chenevert, Robert,Levesque, Carine,Morin, Pierre
experimental part, p. 9501 - 9503 (2009/04/06)
(Chemical Equation Presented) The stereoselective acetylation of meso-2,2-dimethyl-1,3-cyclohexanediol by vinyl acetate in the presence of three lipases gave the (1R,3S)-monoester in high enantiomeric excess (ee ≥ 98%). The hydrolysis of the corresponding meso-diacetate in the presence of Candida antarctica lipase in phosphate buffer provided the opposite enantiomer. Optically active monoacetates were converted to both enantiomers of 3-hydroxy-2,2-dimethylcyclohexanone, a versatile chiral building block.
