1091629-60-5Relevant articles and documents
Catalytic enantioselective Michael addition of 1-fluoro-bis (phenylsulfonyl)methane to α,β-unsaturated ketones catalyzed by cinchona alkaloids
Furukawa, Tatsuya,Shibata, Norio,Mizuta, Satoshi,Nakamura, Shuichi,Toru, Takeshi,Shiro, Motoo
, p. 8051 - 8054 (2008)
(Chemical Equation Presented) A catalyst worth its salt: The ammonium salts of cinchona alkaloids possessing sterically demanding substituents effectively catalyzed the enantioselective 1,4-conjugate addition of 1-fluorobis(phenyl- sulfonyl) methane to α,β-unsaturated ketones to furnish the Michael adducts in high yield with excellent enantioselectivity (see scheme). The adducts are useful for the synthesis of chiral monofluoromethylated molecules.