109185-21-9

Basic information

• Product Name: 2-hydroxy-N-(4-ethoxyphenyl)-2-methylpropionamide
• Synonyms: 2-hydroxy-N-(4-ethoxyphenyl)-2-methylpropionamide
• CAS NO: 109185-21-9
• Molecular Weight: 223.272
• Mol File: 109185-21-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-N-(4-ethoxyphenyl)-2-methylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-(4-ethoxyphenyl)-2-methylpropionamide(109185-21-9)
• EPA Substance Registry System: 2-hydroxy-N-(4-ethoxyphenyl)-2-methylpropionamide(109185-21-9)

Safety Data

• Hazardous Substances Data: 109185-21-9(Hazardous Substances Data)

Upstream product

• 857808-79-8 α-acetoxy-isobutyric acid p-phenetidide 
• 594-61-6 2-methyllactic acid 
• 156-43-4 4-Ethoxyaniline 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 7462-74-0 2-bromo-2-methylpropanamide 
• 622-62-8 4-Ethoxyphenol 
• 134420-06-7 p-ethoxy phenyl isonitrile 

Relevant articles and documents

PROCESS FOR ALKYLATING AND SMILES REARRANGEMENT OF HYDROXY AROMATICS

The present invention is a process of converting a hydroxy aromatic into a 2-hydroxy-N-arylacetamide, comprising: (1) treating a reaction mixture comprising a salt of a hydroxy aromatic with an alkylating agent; and (2) treating the reaction mixture with

Preparation of N-Aryl-2-hydroxypropionamides from hydroxy aromatic compounds using a one-pot smiles rearrangement procedure

Acylation of hydroxy aromatic compounds with 2-bromo-2-methylpropionamide followed by Smiles rearrangement of the resulting 2-aryloxypropionamide in a one-pot procedure produced the corresponding 2-hydroxy-2-methyl-N-arylpropionamides which can be converted to arylamines by hydrolysis. Particularly important applications of this new process were the conversions of estrone (6) and estradiol (14) to the corresponding 3-aminoestrahriene derivatives 8 and 15, respectively. In addition, an improved Semmler-Wolff procedure is described for the conversion of 19-nortestosterone (22) to 3-aminoestra-1,3,5(10)-uien-17β-ol hydrochloride (26).