1092115-58-6Relevant articles and documents
Design and synthesis of N-hydroxytriazole-4-carboxamides as HIV integrase inhibitors
Bai, Yue-Xia,Li, Long-Ji,Wang, Xiao-Li,Zeng, Cheng-Chu,Hu, Li-Ming
, p. 423 - 429 (2015)
A series of N-hydroxytriazole-4-carboxamide derivatives were synthesized, and their potential HIV integrase inhibitory activities were evaluated.
Using the same hydroxamic acid derivative and HDAC8 inhibitor (by machine translation)
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Paragraph 0075-0077; 0145, (2016/10/09)
Disclosed are: a compound which is capable of inhibiting the function of HDAC8; and an HDAC8 inhibitor. Specifically disclosed is a hydroxamic acid derivative which is characterized by being composed of a compound represented by general formula (1) (wherein X represents an aromatic substituent or an optionally substituted 3-8 membered ring, and n represents an integer of 0-20), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.
Histone deacetylase inhibitors through click chemistry
Shen, Jie,Woodward, Robert,Kedenburg, James Patrick,Liu, Xianwei,Chen, Min,Fang, Lanyan,Sun, Duxin,Wang, Peng George
experimental part, p. 7417 - 7427 (2009/12/26)
Histone deacetylase inhibitors (HDACi) are a relatively new class of chemotherapy agents. Herein, we report a click-chemistry based approach to the synthesis of HDACi. Fourteen agents were synthesized from the combination of two alkyne and seven azido pre
