109232-37-3

Usage

Uses

Due to the limited information available on Isobutyl 5-chloro-2,2-dimethylvalerate, its specific applications are not well-documented. However, as an ester, it may have potential uses in various industries, such as:
Used in Chemical Synthesis:
Isobutyl 5-chloro-2,2-dimethylvalerate could be used as an intermediate in the synthesis of more complex organic compounds, given its unique structure and functional groups.
Used in Pharmaceutical Industry:
Although not explicitly mentioned, esters are often used in the pharmaceutical industry as precursors for the synthesis of drugs or as components in drug delivery systems.
Used in Agrochemical Industry:
Esters are sometimes used in the agrochemical industry, potentially as components in the formulation of pesticides or other agricultural chemicals.

InChI:InChI=1/C11H21ClO2/c1-9(2)8-14-10(13)11(3,4)6-5-7-12/h9H,5-8H2,1-4H3

Upstream product

• 97-85-8 isobutyl isobutanoate 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 1343498-60-1 isobutyl 2,2-dimethyl-5-(4-phenoxyphenoxy)pentanoate 
• 1343498-59-8 isobutyl 5-(4-benzoylphenoxy)-2,2-dimethylpentanoate 
• 1343498-61-2 isobutyl 2,2-dimetyl-5-{4-[(E)-phenyldiazenyl]phenoxy}pentanoate 
• 1225796-29-1 2,2-dimethyl-5-(o-tolyloxy)pentanoic acid 

Relevant academic research and scientific papers

Preparation method of 5-chloro-2,2-dimethyl isobutyl valerate

The invention relates to a preparation method of 5-chloro-2,2-dimethyl isobutyl valerate, which comprises the steps of carrying out heat exchange treatment and reaction on a phase A and a phase B, sequentially adding an isobutyl isobutyrate phase C, a 1,3-bromochloropropane phase D and a diluted hydrochloric acid phase E, reacting, quenching in a quenching module, and carrying out after-treatmentto obtain 5-chloro-2,2-dimethyl isobutyl valerate. According to the preparation method, metal lithium is replaced by n-butyllithium, so that the safety risk in the reaction process is reduced; a continuous flow micro-channel reactor is adopted, so that the reaction time is remarkably shortened, and the reaction efficiency is greatly improved; and the purity of the product reaches 97% or above, andthe yield reaches 91% or above.

Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study

Previous studies demonstrated that anti-hyperlipidemic drug gemfibrozil acts as NO- and heme-independent activator of NO receptor soluble guanylyl cyclase. A series of new gemfibrozil derivatives were synthesized and evaluated for sGC activation. The structure-activity relationship study identified the positions in gemfibrozil's scaffold that are detrimental for sGC activation and those that are amendable for optimizing modifications. Compared with gemfibrozil, compounds 7c and 15b were more potent activators of cGMP-forming activity of purified sGC and exhibited enhanced relaxation of preconstricted mouse thoracic aorta rings. These studies established the overall framework needed for futher improvement of sGC activators based on gemfibrozil scaffold.

Preparation method of 5,5-dimethyl-2-cyanocyclopentanone

The invention relates to a preparation method of 5,5-dimethyl-2-cyanocyclopentanone and a preparation method of a related intermediate 2,2-dimethyl-5-(4-chlorobenzyl)cyclopentanone and an application thereof to synthesis of a bactericide metconazole. Cholesteryl iso-butyrate, 1,3-dihalogenated propane, a cyanidation agent, p-chlorobenzyl chloride, and the like are used as main raw materials, multiple steps of reactions are used for preparation and separation, compared with a traditional process, the technique implementation is convenient and yield is high, and the methods have good industrial application prospects.

Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid

An improved two-step process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (gemfibrozil) which regularly affords gembibrozil in overall yields in excess of 80% comprises reacting an alkali metal salt of a lower alkyl ester of 2-methylpropanoic acid with 1,3-dibromopropane or 1-bromo-3-chloropropane in a polar aprotic solvent such as tetrahydrofuran, and then reacting the intermediate thus formed with an alkali metal salt of 2,5-dimethylphenol in a mixed toluene/dimethylsulfoxide solvent system.