109244-58-8 Usage
Uses
Used in Cellular and Molecular Research:
Dihydrorhodamine 123 is used as a detection agent for reactive oxygen species (ROS) in various cell types, such as head kidney-derived macrophages, red blood cells, and neutrophils. It helps in understanding the role of ROS in cellular processes and their involvement in various diseases.
Used in Antioxidant Studies:
DHR is employed as a tool to study the effects of antioxidants on the production of reactive oxygen intermediates. By monitoring the fluorescence or absorbance of rhodamine, researchers can assess the antioxidant capacity of different compounds or treatments.
Used in Pharmaceutical Research:
Dihydrorhodamine 123 is used as a probe to investigate the production of reactive oxygen intermediates in drug discovery and development. It can help identify potential drug candidates that modulate ROS production and may have therapeutic applications in various diseases.
Used in Diagnostic Applications:
DHR can be utilized in the development of diagnostic tools for detecting and monitoring oxidative stress in various conditions, such as inflammation, ischemia, and neurodegenerative diseases.
Used in Environmental and Toxicology Studies:
Dihydrorhodamine 123 is used as a biomarker for assessing the oxidative stress caused by environmental pollutants and toxins. It can help in understanding the mechanisms of toxicity and developing strategies for mitigating the harmful effects of these substances.
Used in Analytical Chemistry:
DHR can be employed as a sensitive and selective probe for the detection and quantification of reactive oxygen species in various chemical and biological samples, providing valuable information for research and quality control purposes.
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 109244-58-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,2,4 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 109244-58:
(8*1)+(7*0)+(6*9)+(5*2)+(4*4)+(3*4)+(2*5)+(1*8)=118
118 % 10 = 8
So 109244-58-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H18N2O3/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20/h2-11,20H,22-23H2,1H3
109244-58-8Relevant academic research and scientific papers
Kinsey, Berma M.,Kassis, Amin I.,Fayad, Fahed,Layne, Warren W.,Adelstein, S. James
, p. 1757 - 1761 (1987)
Rhodamine 123, a mitochondrial stain that preferentially accumulates in certain cancer cells, has been reduced and iodinated by using NaI in the presence of N-chlorosuccinimide.The various mono-, di-, and triiodo derivatives have been isolated and charact
A significant improvement of the efficacy of radical oxidant probes by the kinetic isotope effect
Kundu, Kousik,Knight, Sarah F.,Lee, Seungjun,Taylor, W. Robert,Murthy, Niren
supporting information; experimental part, p. 6134 - 6138 (2010/12/20)
A breath of fresh air: The rate of aerial oxidation of dihydroethidium and hydrocyanine radical oxidant probes can be selectively reduced by deuteration (see picture). The reaction rate between the deuterated compounds and the superoxide radical was reduced by a much smaller factor because of mechanistic differences between the two reactions.
