1092474-91-3Relevant academic research and scientific papers
Isatin Derivatives Containing Sterically Hindered Phenolic Fragment and Water-Soluble Acyl Hydrazones on Their Basis: Synthesis and Antimicrobial Activity
Bogdanov,Zaripova,Voloshina,Strobykina,Kulik,Bukharov,Mironov
, p. 57 - 67 (2018)
Condensation reactions of isatin derivatives with 3,5-di(tert-butyl)-4-hydroxybenzyl acetate and the Girard’s reagent T has afforded a series of novel water-soluble isatin-3-acyl hydrazones containing a sterically hindered phenolic fragment in position 1 of the heterocycle; antimicrobial activity of the products has been estimated. It has been shown that the isatin derivatives with bromine or methoxy substituent in the benzo fragment as well as the acyl hydrazones containing 5-methyl or 5-ethyl group are the most active against Staphylococcus aureus and Bacillus cereus.
Isatin acylhydrazones with sterically hindered phenolic fragments: Synthesis and structures
Nugumanova,Tagasheva,Bukharov,Krivolapov,Litvinov,Syakaev,Mukmeneva,Burilov
experimental part, p. 1934 - 1938 (2011/01/09)
Isatin acylhydrazones with sterically hindered phenolic fragments were obtained. Their structures were determined using 1D and 2D 1H and 13C NMR spectroscopy and X-ray diffraction. The products synthesized by condensation of isatin and 1-(3,5-di- tert-butyl-4-hydroxybenzyl)-l H-indole-2,3-dione with 3-(3,5-di- tert-butyl-4-hydroxyphenyl)propiono-hydrazide exist as E- and Z-isomers about the C=N bond. E- Z isomerization takes place in boiling ethanol. The E-isomer of the condensation product from isatin and 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionohydrazide was structurally characterized using X-ray diffraction: this isomer is a cis-conformer about the amide group and has a E-configuration about the N-N bond. According to data on the concentration dependence of the signals for the NH protons in the 1H NMR spectra, the acylhydrazones obtained are stabilized in solution by intra-and intermolecular hydrogen bonding.
Synthesis of sterically hindered phenolic compounds from indole and its derivatives
Nugumanova,Bukharov,Tagasheva,Kurapova,Syakaev,Mukmeneva,Gurevich,Burilov
experimental part, p. 1797 - 1803 (2009/09/29)
Reactions of 3,5-di-tert-butyl-4-hydroxybenzyl acetate with indole and its derivatives gave a series of sterically hindered phenolic compounds having various functional groups. The products are potentially capable of inhibiting radical chain oxidation processes according to different mechanisms.
