1092533-01-1

Basic information

• Product Name: 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile
• Synonyms: 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile
• CAS NO: 1092533-01-1
• Molecular Weight: 363.475
• Mol File: 1092533-01-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile(1092533-01-1)
• EPA Substance Registry System: 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile(1092533-01-1)

Safety Data

• Hazardous Substances Data: 1092533-01-1(Hazardous Substances Data)

Upstream product

• 36982-56-6 (2-bromoethyl)cyclopropane 
• 1092531-45-7 4-(4-fluorophenyl)-4-hydroxy-1-phenylcyclohexanecarbonitrile 

Downstream Products

• 1092530-05-6 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarboxylic acid 

Relevant articles and documents

DI(HETERO)ARYLCYCLOHEXANE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula (I), in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula (I), their use and pharmaceutical compositions comprising them.