36982-56-6

Basic information

• Product Name: 2-Cyclopropylethyl bromide
• Synonyms: (2-Bromoethyl)cyclopropane;2-Cyclopropylethyl bromide
• CAS NO: 36982-56-6
• Molecular Formula: C₅H₉Br
• Molecular Weight: 149.02896
• Mol File: 36982-56-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 129℃
• Flash Point: 39.2±13.6℃
• Appearance: /
• Density: 1.433±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 2-Cyclopropylethyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropylethyl bromide(36982-56-6)
• EPA Substance Registry System: 2-Cyclopropylethyl bromide(36982-56-6)

Safety Data

• Hazardous Substances Data: 36982-56-6(Hazardous Substances Data)

Usage

Uses

2-Bromoethylcyclopropane is used as a reagent to synthesize 22-Hydroxycholesterol (H918010) derivatives, compounds that act as serum cholesterol lowering agents. 2-Bromoethylcyclopropane is also used to prepare pyridazinones, compounds that act as cyclooxygenase 2-inhibitors (they possess anti-inflammatory and antiangiogenic effects).

Upstream product

• 34108-21-9 methyl cyclopropylacetate 
• 14902-14-8 -triphenyl-phosphoran 
• 5239-82-7 cyclopropylacetic acid 
• 62893-54-3 2-(cyclopropyl)ethylamine 
• 6542-60-5 2-cyclopropylacetonitrile 
• 2566-44-1 1-cyclopropylethanol 
• 861787-21-5 N-(2-cyclopropyl-ethyl)-benzamide 

Downstream Products

• 94361-26-9 2-(4-chlorophenyl)-3-cyclopropyl-1,2-butylene oxide 
• 94361-06-5 cyproconazol 
• 1445848-01-0 potassium 2-cyclopropyl-ethyl-trifluoroborate 
• 1092533-01-1 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile 
• 1040542-24-2 ethyl 2-(2-cyclopropylethyl)-5-hydroxy-3-oxo-6-phenyl-2,3-dihydro-4-pyridazinecarboxylate 

Relevant articles and documents

SYNTHESIS AND STRUCTURE OF cis-PtX2(P(t-Bu)2CH2CH2CH=CHCH3) (X = Cl, Br), A PLATINUM ?-OLEFIN COMPLEX FORMED BY THE INTRAMOLECULAR ACTIVATION OF A CYCLOPROPYLPHOSPHINE

The mixed chloro/bromo ?-olefin complexes cis-PtX2(P(t-Bu)2CH2CH2CH=CHCH3) (2) have been prepared by the reaction of Zeise's salt (K) with in boiling ethanol.The dimer complexes (1) (X, Y = Cl or Br) form first with subsequent activation of cyclopropane to give the monomeric ?-olefin complexes (2).The mixed ?-olefin complexes 2 co-crystallize.The average structure of 2 has been determined by X-ray methods.The relative occupancies in bromine for halogen sites cis- and trans- to coordinated olefin are 0.464(6) and 0.256(6), respectively.The olefin is symmetrically bound to the Pt atom (Pt-C 2.17(1) Angstroem).The olefinic C-C bond length is 1.38(1) Angstroem.

22-Hydroxycholesterol Derivatives as HMG CoA Reductase Suppressors and Serum Cholesterol Lowering Agents

A series of 22-hydroxycholesterol derivatives with a modified side chain terminus was prepared.These agents were evaluated in vitro and in vivo for their ability to suppress HMG CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis.In tissue culture assays, 22-hydroxycholesterol as well as the side chain modified analogues were potent inhibitors of HMG CoA reductase.However, only those sterols with a modified side chain terminus were effective suppressors of liver reductase whene administered ig to rats. 22-Hydroxy-25-methylcholesterol (4a) and 25-fluoro-22-hydroxycholesterol (15a) significantly lowered serum cholesterol levels when administered ig to primates; 25-chloro-22-hydroxycholesterol (15b) and the analogue with a cyclopropyl terminus, 20b, were ineffective.The cholesterol-lowering sterols did not significantly alter lipoprotein levels; however, the two compounds have been shown to inhibit acyl-coenzyme A:cholesterol-transferase (ACAT) in tissue culture studies

24-Cyclopropylcholene-3β, 22-diols and esters thereof

24-Cyclopropylcholene-3β, 22-diols and esters thereof which control serum cholesterol levels and their preparation are disclosed.