36982-56-6

Basic information

• Product Name: 2-Cyclopropylethyl bromide
• Synonyms: (2-Bromoethyl)cyclopropane;2-Cyclopropylethyl bromide
• CAS NO: 36982-56-6
• Molecular Formula: C₅H₉Br
• Molecular Weight: 149.02896
• Mol File: 36982-56-6.mol

Chemical Properties

• Boiling Point: 129℃
• Flash Point: 39.2±13.6℃
• Appearance: /
• Density: 1.433±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 2-Cyclopropylethyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropylethyl bromide(36982-56-6)
• EPA Substance Registry System: 2-Cyclopropylethyl bromide(36982-56-6)

Safety Data

• Hazardous Substances Data: 36982-56-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyclopropylethyl bromide is used as a synthetic reagent for the production of 22-Hydroxycholesterol (H918010) derivatives. These derivatives are known to act as serum cholesterol-lowering agents, making them valuable in the development of treatments for hypercholesterolemia and related cardiovascular conditions.
Additionally, 2-Cyclopropylethyl bromide is used in the preparation of pyridazinones, which are compounds that act as cyclooxygenase 2-inhibitors. These inhibitors possess anti-inflammatory and antiangiogenic effects, making them potential candidates for the development of drugs to treat inflammation and angiogenesis-related diseases, such as arthritis and cancer.

Upstream product

• 34108-21-9 methyl cyclopropylacetate 
• 5239-82-7 cyclopropylacetic acid 
• 62893-54-3 2-(cyclopropyl)ethylamine 
• 6542-60-5 2-cyclopropylacetonitrile 
• 2566-44-1 1-cyclopropylethanol 
• 861787-21-5 N-(2-cyclopropyl-ethyl)-benzamide 
• 14902-14-8 -triphenyl-phosphoran 

Downstream Products

• 5618-03-1 3-cyclopropanepropionic acid 
• 94361-26-9 2-(4-chlorophenyl)-3-cyclopropyl-1,2-butylene oxide 
• 94361-06-5 cyproconazol 
• 1445848-01-0 potassium 2-cyclopropyl-ethyl-trifluoroborate 
• 1092533-01-1 4-(2-cyclopropylethoxy)-4-(4-fluorophenyl)-1-phenylcyclohexanecarbonitrile 

Relevant articles and documents

SYNTHESIS AND STRUCTURE OF cis-PtX2(P(t-Bu)2CH2CH2CH=CHCH3) (X = Cl, Br), A PLATINUM ?-OLEFIN COMPLEX FORMED BY THE INTRAMOLECULAR ACTIVATION OF A CYCLOPROPYLPHOSPHINE

The mixed chloro/bromo ?-olefin complexes cis-PtX2(P(t-Bu)2CH2CH2CH=CHCH3) (2) have been prepared by the reaction of Zeise's salt (K) with in boiling ethanol.The dimer complexes (1) (X, Y = Cl or Br) form first with subsequent activation of cyclopropane to give the monomeric ?-olefin complexes (2).The mixed ?-olefin complexes 2 co-crystallize.The average structure of 2 has been determined by X-ray methods.The relative occupancies in bromine for halogen sites cis- and trans- to coordinated olefin are 0.464(6) and 0.256(6), respectively.The olefin is symmetrically bound to the Pt atom (Pt-C 2.17(1) Angstroem).The olefinic C-C bond length is 1.38(1) Angstroem.

N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS

The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example

Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use

Compounds of the formula (I): STR1 wherein R1, R3, R4, R5 and R6 have defined values and the N-oxides at the 7-position of the pyrazolo[3,4-b]pyridine ring system and the pharmaceutically-acceptable acid-addition salts thereof, processes for their preparation and use, pharmaceutical compositions, and intermediates for preparing said compounds of the formula (I). The compounds of formula (I) are central nervous system depressants, for example anxiolytic agents.

22-Hydroxycholesterol Derivatives as HMG CoA Reductase Suppressors and Serum Cholesterol Lowering Agents

A series of 22-hydroxycholesterol derivatives with a modified side chain terminus was prepared.These agents were evaluated in vitro and in vivo for their ability to suppress HMG CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis.In tissue culture assays, 22-hydroxycholesterol as well as the side chain modified analogues were potent inhibitors of HMG CoA reductase.However, only those sterols with a modified side chain terminus were effective suppressors of liver reductase whene administered ig to rats. 22-Hydroxy-25-methylcholesterol (4a) and 25-fluoro-22-hydroxycholesterol (15a) significantly lowered serum cholesterol levels when administered ig to primates; 25-chloro-22-hydroxycholesterol (15b) and the analogue with a cyclopropyl terminus, 20b, were ineffective.The cholesterol-lowering sterols did not significantly alter lipoprotein levels; however, the two compounds have been shown to inhibit acyl-coenzyme A:cholesterol-transferase (ACAT) in tissue culture studies

24-Cyclopropylcholene-3β, 22-diols and esters thereof

24-Cyclopropylcholene-3β, 22-diols and esters thereof which control serum cholesterol levels and their preparation are disclosed.