1092546-76-3Relevant academic research and scientific papers
Synthesis and antibacterial activity of a new series of 2,3,5,7-substituted-pyrido[2,3-d/]pyrimidin-4(3H)-one derivatives
Bheemanapalli, Lakshmi Narayana,Akkinepally, Raghuram Rao,Pamulaparthy, Shanthan Rao
experimental part, p. 1342 - 1348 (2009/09/25)
A new series of 2,3,5,7-substituted-pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were prepared from 2-amino-N,6-substituted phenyl-4-(trifluoromethyl or methyl)nicotinamides. The key intermediate 2-amino-N,6-substituted phenyl-4-(trifluoromethyl or methyl)nicotinamides were synthesized from 2-bromo-N,6-disubstituted phenyl-4-(trifluoromethyl or methyl)nicotinamides as well as fromethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) coupling of 2-amino-4,6-substituted nicotinic acid and substituted arylamines. All the synthesized compounds were screened for antibacterial activity against Gram +ve and Gram -ve bacteria. Compound 7c showed better antibacterial activity against Gram +ve and Gram -ve bacteria.
