114192-88-0

Upstream product

• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 1172603-97-2 4,4,4-trifluoro-N-methoxy-N-methylbut-2-enamide 
• 591-51-5 phenyllithium 
• 149846-93-5 1-phenyl-4,4,4-trifluorobut-2-yn-1-ol 
• 100-52-7 benzaldehyde 
• 676-83-5 methyldichlorophosphane 
• 1524-15-8 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 188429-64-3 2,2,2-trifluoro-N,N,N',N'-tetramethylethane-1,1-diamine 
• 325704-95-8 4,4,4-trifluoro-3-N,N-dimethylamino-1-phenyl-1-butanone 
• 136964-14-2 (Z)-1-phenyl-4,4,4-trifluoro-2-buten-1-one 
• 98-86-2 acetophenone 
• 123-75-1 pyrrolidine 

Downstream Products

• 119982-27-3 3-benzoyl-4-trifluoromethylpyrrole 
• 1092546-76-3 N-(4-chlorophenyl)-2-cyano-5-oxo-5-phenyl-3-(trifluoromethyl)pentanamide 
• 1246025-24-0 (R)-4,4,4-trifluoro-3-(7-methyl-1H-indol-3-yl)-1-phenylbutan-1-one 
• 1316228-02-0 4,4,4-trifluoro-3-(5-fluoro-1H-indol-3-yl)-1-phenylbutan-1-one 
• 1246025-21-7 (R)-4,4,4-trifluoro-3-(5-methyl-1H-indol-3-yl)-1-phenylbutan-1-one 
• 1316227-98-1 4,4,4-trifluoro-3-(5-methyl-1H-indol-3-yl)-1-phenylbutan-1-one 
• 1361996-67-9 4-methyl-N-(1,1,1-trifluoro-3-iodo-4-oxo-4-phenylbutan-2-yl)benzenesulfonamide 
• 1361996-68-0 4-methyl-N-(1,1,1-trifluoro-3-bromo-4-oxo-4-phenylbutan-2-yl)benzenesulfonamide 
• 1361996-69-1 4-methyl-N-(1,1,1-trifluoro-3-chloro-4-oxo-4-phenylbutan-2-yl)benzenesulfonamide 
• 1246025-11-5 (3R)-4,4,4-trifluoromethyl-3-(1H-indol-3-yl)-1-phenylbutan-1-one 
• 1246025-22-8 (R)-3-(5-bromo-1H-indol-3-yl)-4,4,4-trifluoro-1-phenylbutan-1-one 

Relevant academic research and scientific papers

Synthesis of Trifluoromethylated Amines Using 1,1-Bis(dimethylamino)-2,2,2-trifluoroethane

Lewis acid-catalyzed deamination of aminal, 1,1-bis(dimethylamino)-2,2,2-trifluoroethane, using ZnI2 in ether, generates the 2,2,2-trifluoro-1,1-dimethylaminoethyl carbocation, which undergoes synthetically useful electrophilic reactions with a

Facile synthesis of trifluoromethyl carbinols and trifluoromethyl- α,β-unsaturated ketones from the new CF3CHO synthetic equivalent, 1,1- bis(dimethylamino)-2,2,2-trifluoroethane

1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCl catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbino

Sodium carbonate as carbon dioxide source for the synthesis of cyclic carbonates containing the trifluoromethyl group

Trifluoromethylated cyclic carbonates were prepared through the palladium-promoted reaction of tertiary trifluoromethylated propargylic alcohols and sodium carbonate.

Trifluoromethylated 1,2λ5σ4-oxaphospholanes via λ5σ5P tricyclic phosphoranes from 4,4,4-trifluoro-3-hydroxy-1-phenylbutane-1-one and dichlorophosphines. Molecular structure of a trapped phosphonite

Reacting 4,4,4-trifluoro-3-hydroxy-1-phenylbutane-1-one (1) with the dichlorophosphines RPCl2 (2a, R = Me; 2b, R = Ph) gave the phosphonites 3a and 3b, which, in the case of 3a, was trapped using hexafluoroacetone to furnish the 1,3,2λ5/s

Highly Enantioselective [3 + 2] Annulation of 3-Butynoates with β-Trifluoromethyl Enones Promoted by an Amine-Phosphine Binary Catalytic System

We report a highly enantioselective [3 + 2] annulation between 3-butynoates and β-trifluoromethyl enones, furnishing trifluoromethylated cyclopentenes with three contiguous stereogenic centers in good yields, high diastereoselectivities, and excellent enantioselectivities. A unique catalytic system consisting of a simple amine and a chiral phosphine was devised, and the synergistic play of Lewis basic amine and phosphine was crucial for alkyne isomerization and subsequent cyclization. The protocol disclosed herein allows facile activation of 3-butynoates in phosphine-mediated asymmetric transformations.

Oxidation of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoro?-methanesulfonates by 4-Picoline-N-Oxide: A Novel Approach to β-Trifluoromethyl-α,β-enones

An efficient approach to β-trifluoromethyl-α,β-enones via oxidation of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates is described. The reaction proceeds smoothly under mild and metal?-free conditions and tolerates a wide range of functional groups. Various β-trifluoromethyl-α,β-enones were obtained in moderate to good yields.

Preparation method of (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound

The invention discloses a preparation method of an (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound, and belongs to the field of compound preparation. The (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound is prepared by taking a compound shown

Chiral Hydroxytetraphenylene-Catalyzed Asymmetric Conjugate Addition of Boronic Acids to Enones

(S)-2,15-Br2-DHTP-catalyzed asymmetric conjugate addition of boronic acids to β-trifluoromethyl α,β-unsaturated ketones and enones was studied. The reaction afforded the corresponding Michael addition products in moderate to high yields with excellent enantioselectivities (up to 99:1 er). This catalytic system features mild reaction conditions, high efficiency, and tolerance to heteroarylboronic acids.

Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones

A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi

Rh(III)-Catalyzed [3 + 2] Annulation via C-H Activation: Direct Access to Trifluoromethyl-Substituted Indenamines and Aminoindanes

The rhodium(III)-catalyzed direct C-H addition and annulation of benzimidates and aldimines with β-(trifluoromethyl)-α,β-unsaturated ketones is described. This protocol provides the facile and efficient formation of various trifluoromethyl-containing inde