1092579-96-8

Basic information

• Product Name: 4-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 4-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine;4-(TrifluoroMethyl)-7-azaindole
• CAS NO: 1092579-96-8
• Molecular Formula: C8H5F3N2
• Molecular Weight: 186.1339096
• EINECS: -0
• Mol File: 1092579-96-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine(1092579-96-8)
• EPA Substance Registry System: 4-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine(1092579-96-8)

Safety Data

• Hazardous Substances Data: 1092579-96-8(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is a chemical compound with the molecular formula C8H5F3N2. It is a heterocyclic compound containing a pyrrolopyridine core structure with a trifluoromethyl group attached. 4-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules, including potential drug candidates. It is also used as a research tool in the development of new drugs and chemical entities. The trifluoromethyl group in the compound enhances its lipophilicity and can improve its pharmacokinetic properties, making it an attractive target for drug discovery and development.

InChI:InChI=1S/C8H5F3N2/c9-8(10,11)6-2-4-13-7-5(6)1-3-12-7/h1-4H,(H,12,13)

Upstream product

• 1146221-86-4 1-tert-butyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 

Relevant articles and documents

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease.

Synthesis of fluorinated pyrrolo[2,3-b]pyridine and pyrrolo[2,3-d] pyrimidine nucleosides

With the purpose of synthesizing novel ADAs (adenosine deaminase) and IMPDH (inosine 5′-monophosphate dehydrogenase) inhibitors the reactions of 5-amino-1-tert-butyl-1-H-pyrrole-3-carbonitrile with fluorinated 1,3 - bielectrophiles were studied. An effici