109271-22-9Relevant academic research and scientific papers
Synthesis of 3β-Hydroxy-5β-pregn-8(14)-en-20-one from Chenodeoxycholic Acid
Deluca, Monica E.,Seldes, Alicia M.,Gros, Eduardo G.
, p. 1844 - 1850 (1986)
3β-Hydroxy-5β-pregn-8(14)-en-20-one (17) was prepared from chenodeoxycholic acid (1a).The synthetic sequence involved: i) degradation of the bile-acid side chain to an etianic acid; ii) formation of the 8(14)-double bond;iii) inversion of the configuration at C(3);iv) construction of the acetyl side chain at C(17) with the required isotopic label at C(21).Structures of all described products were confirmed by chemical and spectroscopic (IR,1H-NMR, 13C-NMR,MS) methods.
