109273-24-7Relevant articles and documents
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
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, (2008/06/13)
A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.
Peptide nucleic acids having 2,6-diaminopurine nucleobases
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, (2008/06/13)
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8alkylamine side chains.
Vitronectin receptor antagonists
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, (2008/06/13)
PCT No. PCT/US98/00490 Sec. 371 Date Jun. 29, 1999 Sec. 102(e) Date Jun. 29, 1999 PCT Filed Jan. 8, 1998 PCT Pub. No. WO98/30542 PCT Pub. Date Jul. 16, 1998This invention relates to certain tricyclic compounds that are integrin receptor antagonists.