166410-28-2

Basic information

• Product Name: Carbamic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester
• CAS NO: 166410-28-2
• Molecular Formula: C22H26N2O4
• Mol File: 166410-28-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester(166410-28-2)
• EPA Substance Registry System: Carbamic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 9H-fluoren-9-ylmethyl ester(166410-28-2)

Safety Data

• Hazardous Substances Data: 166410-28-2(Hazardous Substances Data)

Upstream product

• 57260-73-8 N-BOC-1,2-diaminoethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 213322-15-7 N-(9H-fluorenylmethoxycarbonyloxy)succinimide 
• 109273-24-7 2,3-diaminopropionic acid t-butyl ester 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 112670-29-8 N-(tert-butyloxycarbonyl)-1,2-diaminoethane toluensulfonic acid salt 

Downstream Products

• 225797-46-6 {2-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethyl}-carbamic acid tert-butyl ester 
• 166410-32-8 N-Fmoc-ethylenediamine 
• 391624-47-8 [2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-carbamic acid 4-nitro-phenyl ester 
• 391624-46-7 9-fluorenylmethyl N-(2-aminoethyl)carbamate hydrochloride 
• 207129-12-2 N-Boc-N'-Fmoc-imidazolidine-2-carboxylic acid 

Relevant articles and documents

LIGAND LINKER SUBSTRATE

Ligand functionalized substrate including a solid substrate, which has been modified to provide grafted catching ligand groups covalently bound via a linker, methods of preparing said ligand functionalized substrate and the use thereof, such as to increase binding rate and the dynamic binding capacity (DBC).

PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY

This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that permit typical backbone and side chain acid- and base-labile protecting groups to remain substantially intact thereby permitting the high yield of PNA monomer carboxylic acids that are suitable for use in PNA oligomer synthesis. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethyl (TCE), 2,2,2-tribromoethyl (TBE), 2-bromoethyl (2-BE) and 2-iodoethyl groups (2-IE). This invention also pertains to novel methods for the synthesis of Backbone Ester compounds and related Backbone Ester Acid Salts.

A ratiometric fluorescent nanoprobe for H2O2 sensing and in vivo detection of drug-induced oxidative damage to the digestive system

Hydrogen peroxide is a biologically important reactive oxygen species (ROS) and plays crucial roles in living organisms. Herein, a FRET-based ratiometric fluorescent probe has been developed for detecting H2O2in vitro and in vivo. In this nanoprobe, carbon dots serve as the energy donor and carrier for the H2O2 recognition element. This nanoprobe exhibits fast-response, low toxicity, high sensitivity (with a detection limit of 0.5 μM) and selectivity towards H2O2 over other reactive oxygen or nitrogen species. The nanoprobe has been successfully applied in the detection of H2O2 in live cells and in zebrafish larvae. By incubating the nanoprobe with zebrafishes, the nanoprobe can be absorbed by the fishes within 1 h and accumulates mainly in the abdominal region. Due to its small size (～4 nm), the nanoprobe is gradually excreted by zebrafishes without long-term accumulation. Moreover, as the first ratiometric chemoprobe that can detect H2O2in vivo, the nanoprobe has been found capable of detecting and locating endogenous H2O2 in zebrafishes as a result of drug-induced oxidative damage. The successful detection of H2O2 by the nanoprobe in vivo may support its eventual use in clinical applications.