109276-77-9Relevant academic research and scientific papers
CONCISE SYNTHESES OF L-SELENOMETHIONINE AND OF L-SELENOCYSTINE USING RADICAL CHAIN REACTIONS
Barton, Derek H. R.,Bridon, Dominique,Herve, Yolande,Potier, Pierre,Thierry, Josiane,Zard, Samir Z.
, p. 4983 - 4990 (2007/10/02)
L-Selenomethionine and L-selenocystine were prepared in high overall yields from protected L-glutamic and L-aspartic acid derivatives respectively.Irradiation of the mixed anhydrides (esters) derived from 4 (e.g. 15) in the presence of dimethyldiselenide provided the protected L-selenomethionine 16 directly.We have shown that triselenocyanide Se3(CN)2 can serve as an efficient selenocyanating agent for radicals; the selenocyanide group is a good precursor for the diselenide moiety of L-selenocystine.
