109276-80-4Relevant academic research and scientific papers
Expedient Synthesis of Natural (S)-Sinefungin and of its C-6' Epimer
Barton, Derek H. R.,Gero, Stephane D.,Quiclet-Sire, Beatrice,Samadi, Mohammed
, p. 981 - 985 (2007/10/02)
Sinefungin 1a and 6-epi-sinefungin 1b have been prepared from adenosine and L-aspartic acid.The key step in the synthesis was the coupling of the radical derived from 14 with the unsaturated amide 13.The latter was obtained by a radical reaction from L-as
MANIPULATION OF THE CARBOXYL GROUPS OF α-AMINO-ACIDS AND PEPTIDES USING RADICAL CHEMISTRY BASED ON ESTERS OF N-HYDROXY-2-THIOPYRIDONE
Barton, Derek H. R.,Herve, Yolande,Potier, Pierre,Thierry, Josiane
, p. 5479 - 5486 (2007/10/02)
Photolysis of α-amino-acid or peptide esters derived from N-hydroxy-2-thiopyridone in the presence of t-butylthiol affords the expected decarboxylation products in good yield.The reaction can be applied to the α-carboxyl or to the side chain carboxyl of g
CONCISE SYNTHESES OF L-SELENOMETHIONINE AND OF L-SELENOCYSTINE USING RADICAL CHAIN REACTIONS
Barton, Derek H. R.,Bridon, Dominique,Herve, Yolande,Potier, Pierre,Thierry, Josiane,Zard, Samir Z.
, p. 4983 - 4990 (2007/10/02)
L-Selenomethionine and L-selenocystine were prepared in high overall yields from protected L-glutamic and L-aspartic acid derivatives respectively.Irradiation of the mixed anhydrides (esters) derived from 4 (e.g. 15) in the presence of dimethyldiselenide provided the protected L-selenomethionine 16 directly.We have shown that triselenocyanide Se3(CN)2 can serve as an efficient selenocyanating agent for radicals; the selenocyanide group is a good precursor for the diselenide moiety of L-selenocystine.
