1092768-72-3Relevant articles and documents
Small, non-peptide C5a receptor antagonists: Part 1
Blagg, Julian,Mowbray, Charles,Pryde, David C.,Salmon, Gary,Schmid, Esther,Fairman, David,Beaumont, Kevin
scheme or table, p. 5601 - 5604 (2009/06/18)
The optimisation of a series of amides for C5a receptor binding and functional activity, and physicochemical properties is described. The initial hit, 1 (IC50 1 μM), was discovered during high throughput screening, from which highly potent C5a receptor antagonists (e.g. 14, IC50 5 nM) were developed.