32399-13-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(Methylamino)pyridine-3-carboxylic acid is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of bioactive molecules. Its unique structure allows it to be a key component in creating various organic compounds and pharmaceuticals.
Used in Agrochemical Production:
In the agrochemical industry, 2-(Methylamino)pyridine-3-carboxylic acid is utilized as an intermediate, playing a crucial role in the synthesis of compounds that contribute to crop protection and enhancement of agricultural yields.
Used in Medicinal Chemistry Research:
2-(Methylamino)pyridine-3-carboxylic acid serves as a valuable tool in medicinal chemistry research, where its properties are explored and leveraged to advance drug discovery and the creation of new therapeutic agents.
Used in Drug Development:
As a component in drug development, 2-(Methylamino)pyridine-3-carboxylic acid is employed for its potential to enhance the efficacy and functionality of new drugs, contributing to the advancement of medical treatments.

InChI:InChI=1/C7H8N2O2/c1-8-6-5(7(10)11)3-2-4-9-6/h2-4H,1H3,(H,8,9)(H,10,11)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 103976-61-0 ethyl 2-(methylamino)pyridine-3-carboxylate 
• 32399-12-5 2-(N-methylamino)-3-hydroxymethylpyridine 
• 103976-52-9 2-(methylamino)pyridine-3-carboxamide 
• 128271-33-0 Methyl-(3-phenylsulfanylmethyl-pyridin-2-yl)-amine 
• 127555-45-7 1-Methyl-3-phenylsulfanyl-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one 
• 1092768-72-3 C₂₃H₂₈ClN₃O₃ 
• 1239164-10-3 1-(ethylthiomethyl)-3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1,8-naphthyridin-2(1H)-one 
• 1239164-58-9 3-oxo-1-cyclohexenyl 1-(ethylthiomethyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1402844-05-6 benzylidene-2-(methylamino)nicotinic acid hydrazide 

Relevant academic research and scientific papers

HYDROPYRAZINO[1,2-D][1,4]DIAZEPINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1 to R3 and n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

1,8-NAPHTHYRIDIN-2-ONE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1 to R3, m and n are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

HEXAHYDRO-1H-PYRAZINO[1,2-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1 to R3, n and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

A preparation method of the midbody shakang zuo

The invention relates to a preparation method of an isavuconazole intermediate. The isavuconazole intermediate is 2-methylamino-3-pyridylcarbinol. The method comprises the following steps: (1) reacting 2-chloronicotinic acid with methylamine dissolved in a methylamine solution to generate 2-methylamino-3-pyridylformic acid, wherein the methylamine solution is formed by dissolving methylamine in water, methanol or a water-methanol mixture; and (2) reducing the 2-methylamino-3-pyridylformic acid in a solvent in the presence of a reducer sodium borohydride/iodine, sodium borohydride/Lewis acid or red aluminum to obtain the 2-methylamino-3-pyridylcarbinol. The method has the advantages of low cost, high product yield and purity, and mild and controllable conditions, and is suitable for industrial scale-up production.

Design and synthesis of niflumic acid-based N-acylhydrazone derivatives as novel anti-inflammatory and analgesic agents

A new series of niflumic acid-based N-acylhydrazone derivatives 5a-p were synthesized and evaluated for their anti-inflammatory and analgesic activities. Most of the compounds have shown anti-inflammatory activity with a moderate-to-excellent activity range (20-80 % reduction in inflammation). Among them, 3-chlorophenyl 5d and 3-pyridyl derivatives 5o exhibited the most potent anti-inflammatory activity relative to niflumic acid as the reference drug (77, 76, and 70 % reduction in inflammation at 1-h postdrug administration, respectively). Also, molecular simplification of niflumic acid through replacing the N-aryl group with N-methyl group produced compounds 6a-f with anti-inflammatory activity in a quite similar manner to those of their parent derivatives. In this subgroup, 4-pyridyl derivative 6f showed the most potent anti-inflammatory activity relative to niflumic acid (80 % reduction in inflammation at 1-h postdrug administration). The compounds with highest anti-inflammatory activity were subjected to analgesic assays and showed moderate-to-excellent analgesic activities. The compound 5j, 4-methoxy derivative, exhibited the highest analgesic activity relative to niflumic acid (97 and 68 % activity, respectively).

RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES

Provided are 2-pyridone derivatives which have excellent herbicidal activity and exhibit high safety to useful crops and so on; salts thereof; and herbicides containing same. In more detail, 2-pyridone derivatives represented by general formula [I] or agrochemically acceptable salts thereof, and herbicides containing these compounds are provided. In general formula [I], X1 is an oxygen atom or a sulfur atom; X2, X3, and X4 are to each CH or N(O)m; m is an integer of 0 or 1; R1 is a hydrogen atom, a C1-12 alkyl group, or the like; R2 is a halogen atom, a cyano group, or the like; n is an integer of 0 to 4; R3 is a hydroxyl group, a halogen atom, or the like; A1 is C(R11R12); A2 is C(R13R14) or C═O; A3 is C(R15R16); and R11, R12, R13, R14, R15, and R16 are each independently a hydrogen atom or a C1-6 alkyl group.

Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines

2-(Methylamino)nicotinic acid was readily prepared in high yield by reacting 2-chloronicotinic acid with 40% aq MeNH2 under microwave irradiation either at 120 °C for 2 h or at 140 °C for 1.5 h. Subsequently, we found that a range of 2-aminonicotinic acids could be obtained under microwave heating. The optimal reaction conditions involved the use of 3 equiv of amine, water as the solvent and heating at 200 °C for 2 h in the presence of diisopropylethylamine (3 equiv).

OXYTOCIN INHIBITORS

This invention relates to compounds of formula (I).

Substituted 1,3-Dihydro-2H-pyrrolopyridin-2-ones as Potential Antiinflammatory Agents

A series of analogues based on the 1,3-dihydro-2H-pyrrolopyridin-2-one ring system have been synthesized and shown to possess oral antiinflammatory activity in both the reverse passive Arthus reaction (RPAR) pleural cavity assay in rats and in the adjuvant-induced arthritic rat model (AAR).Several members of this series additionally exhibit an inhibitory effect on the in vivo production of prostaglandin- and leukotriene-derived products or arachidonic acid metabolism although these compounds exhibit no significant inhibitory activity against the cyclooxygenase and 5-lipoxygenase enzymes in vitro.Structure-activity relationships in this series are discussed.

Imination of N-Methylazinium Salts by Liquid Ammonia/Potassium Permanganate

Treatment of 1-methylquinolinium-, 1,4-dimethylquinolinium- and 1-methyl-1,X-naphthyridinium iodides (X=5,8) with liquid ammonia/potassium permanganate leads to introduction of the imino group at C-2 forming the 1,2-dihydro-2-imino-1-methylquinolines and 1,2-dihydro-2-imino-1-methyl-1,X-naphthyridines (X=5,8) respectively. 1,2-Dimethylquinolinium iodide, when subjected to treatment with liquid ammonia/potassium permanganate undergoes an oxo-demethylation reaction, yielding 1-methylquinol-2-one.The nmr-measurements of solutions of the above-mentioned salts in liquid ammonia clearly show the formation of ?-adduct, strongly suggesting that these ?-adducts are intermediates in the imination reactions.