1092771-12-4

Basic information

• Product Name: methyl 2-bromo-6-(3'-methoxyphenylamino)isonicotinamide
• Synonyms: methyl 2-bromo-6-(3'-methoxyphenylamino)isonicotinamide
• CAS NO: 1092771-12-4
• Molecular Weight: 337.173
• Mol File: 1092771-12-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-bromo-6-(3'-methoxyphenylamino)isonicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-bromo-6-(3'-methoxyphenylamino)isonicotinamide(1092771-12-4)
• EPA Substance Registry System: methyl 2-bromo-6-(3'-methoxyphenylamino)isonicotinamide(1092771-12-4)

Safety Data

• Hazardous Substances Data: 1092771-12-4(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 119308-57-5 methyl 2,6-dibromoisonicotinate 

Relevant articles and documents

Buchwald-Hartwig Mono-N-arylation with 2,6-dihaloisonicotinic acid derivatives: A convenient desymmetrization method

A method for the Buchwald-Hartwig mono-N-arylation of aniline with methyl 2,6-dichloroisonicotinate using Pd(OAc)2, XPhos, and t-BuONa is reported. Use of m-anisidine under the same conditions resulted in the amidation of the methyl ester. Mono-N-arylation of m-anisidine with 2,6-dichloro-N,N- diisopropylisonicotinamide and 2,6-dibromo-N,N-diisopropylisonicotinamide, however, was successfully achieved using Pd(OAc)2/XPhos/t-BuONa or Pd(OAc)2/(±)-BINAP/K2CO3, respectively. The present study demonstrates the sensitivity of this cross-coupling method to both the steric and electronic nature of the coupling partners. Georg Thieme Verlag Stuttgart.