1092773-21-1

Basic information

• Product Name: (3S)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (1S,2R)-1-amino-2-indanol salt
• Synonyms: (3S)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (1S,2R)-1-amino-2-indanol salt
• CAS NO: 1092773-21-1
• Molecular Formula: C₉H₁₁NO*C₁₂H₁₂O₃
• Molecular Weight: 353.42
• Mol File: 1092773-21-1.mol

Chemical Properties

• Melting Point: 202-203 °C
• Appearance: /
• CAS DataBase Reference: (3S)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (1S,2R)-1-amino-2-indanol salt(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (1S,2R)-1-amino-2-indanol salt(1092773-21-1)
• EPA Substance Registry System: (3S)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (1S,2R)-1-amino-2-indanol salt(1092773-21-1)

Safety Data

• Hazardous Substances Data: 1092773-21-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(3S)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (1S,2R)-1-amino-2-indanol salt is used as a research tool for studying molecular interactions and physiological processes in the field of neurology and central nervous system disorders.
Used in Drug Development:
(3S)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (1S,2R)-1-amino-2-indanol salt is used as a potential therapeutic agent for the treatment of neurological and central nervous system disorders.

Upstream product

• 865233-33-6 (+/-)-5-[1-(4-hydroxy-phenyl)-but-2-ynyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 865233-34-7 4-hydroxy-β-1-propyn-1-ylbenzenepropanoic acid 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 865233-82-5 2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione 
• 1291087-13-2 C₁₈H₁₈O₆ 
• 17474-27-0 5-(4-hydroxy-benzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1146212-20-5 acetic acid 4-(2,2-dimethyl-4,6-dioxo[1,3]dioxan-5-ylidenemethyl)-phenyl ester 

Downstream Products

• 865233-37-0 (3S)-3-[4-(4'-trifluoromethyl-biphenyl-3-ylmethoxy)-phenyl]-hex-4-ynoic acid methyl ester 
• 865231-46-5 [3H]-AMG 837 
• 865233-36-9 (3S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid methyl ester 
• 865233-35-8 (3S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid 

Relevant articles and documents

3-PHENYL-4-HEXYNOIC ACID DERIVATIVES AS GPR40 AGONISTS

A compound of the formula (I)wherein R represents a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated, or a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated and wherein one or more of hydrogen atoms is replaced with fluorine atom; X represents hydrogen atom or halogen atom,and* denotes chiral center, and salts thereof. The compound is useful for the treatment of diseases mediated by GPR40, in particular type II diabetes. (I)

Development of a scalable synthesis of a GPR40 receptor agonist

Early process development and salt selection for AMG 837, a novel GPR40 receptor agonist, is described. The synthetic route to AMG 837 involved the convergent synthesis and coupling of two key fragments, (S)-3-(4-hydroxyphenyl) hex-4-ynoic acid (1) and 3-

Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole r