1291087-13-2

Upstream product

• 17474-27-0 5-(4-hydroxy-benzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1146212-20-5 acetic acid 4-(2,2-dimethyl-4,6-dioxo[1,3]dioxan-5-ylidenemethyl)-phenyl ester 
• 16466-97-0 1-propynylmagnesium bromide 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 865233-37-0 (3S)-3-[4-(4'-trifluoromethyl-biphenyl-3-ylmethoxy)-phenyl]-hex-4-ynoic acid methyl ester 
• 865231-46-5 [3H]-AMG 837 
• 865233-33-6 (+/-)-5-[1-(4-hydroxy-phenyl)-but-2-ynyl]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 865233-34-7 4-hydroxy-β-1-propyn-1-ylbenzenepropanoic acid 
• 1092773-21-1 (3S)-3-(4-hydroxyphenyl)hex-4-ynoic acid (1S,2R)-1-amino-2,3-dihydro-1H-inden-2-ol salt 
• 865233-35-8 (3S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid 
• 865233-36-9 (3S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid methyl ester 

Relevant academic research and scientific papers

Development of a scalable synthesis of a GPR40 receptor agonist

Early process development and salt selection for AMG 837, a novel GPR40 receptor agonist, is described. The synthetic route to AMG 837 involved the convergent synthesis and coupling of two key fragments, (S)-3-(4-hydroxyphenyl) hex-4-ynoic acid (1) and 3-