1092775-19-3Relevant academic research and scientific papers
Pyridinium 1,1′-binaphthyl-2,2′-disulfonates as highly effective chiral Br?nsted acid-base combined salt catalysts for enantioselective mannich-type reaction
Hatano, Manabu,Maki, Toshikatsu,Moriyama, Katsuhiko,Arinobe, Manabu,Ishihara, Kazuaki
, p. 16858 - 16860 (2008)
We have established, for the first time, a practical synthesis of chiral 1,1′-binaphthyl-2,2′-disulfonic acid (BINSA 1) from inexpensive BINOL. An efficient enantioselective catalysis in the Mannich-type reactions of diketones and ketoester equivalents with aldimines was developed using chiral 1?achiral 2,6-diarylpyridine (2) combined salts, which acted as convenient chiral tailor-made Br?nsted acid?base organocatalysts in situ. Copyright
