1092794-25-6

Basic information

• Product Name: Spiro[cyclopropane-1,1'(2'H)-isoquinolin]-3'(4'H)-one
• Synonyms: Spiro[cyclopropane-1,1'(2'H)-isoquinolin]-3'(4'H)-one
• CAS NO: 1092794-25-6
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21
• Mol File: 1092794-25-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Spiro[cyclopropane-1,1'(2'H)-isoquinolin]-3'(4'H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[cyclopropane-1,1'(2'H)-isoquinolin]-3'(4'H)-one(1092794-25-6)
• EPA Substance Registry System: Spiro[cyclopropane-1,1'(2'H)-isoquinolin]-3'(4'H)-one(1092794-25-6)

Safety Data

• Hazardous Substances Data: 1092794-25-6(Hazardous Substances Data)

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 20921-96-4 methyl 2-(2-cyanophenyl)acetate 

Relevant articles and documents

BICYCLOANILINE DERIVATIVE

The invention relates to a compound of a general formula (I): wherein A1 and A2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.