1092796-49-0

Basic information

• Product Name: 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide
• Synonyms: 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide
• CAS NO: 1092796-49-0
• Molecular Weight: 396.443
• Mol File: 1092796-49-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide(1092796-49-0)
• EPA Substance Registry System: 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid [3-(4-methoxy-phenyl)-3-oxopropyl]-amide(1092796-49-0)

Safety Data

• Hazardous Substances Data: 1092796-49-0(Hazardous Substances Data)

Upstream product

• 380607-13-6 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid 

Downstream Products

• 1092796-30-9 7,8-dimethoxy-5-(4-methoxyphenyl)-10-methyl-3,10-dihydro-2H-azepino[3,4-b]indol-1-one 

Relevant articles and documents

Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted β-carbolin-1-ones

A series of β-carbolin-2-ones and 3,10-dihydro-2H-azepino[3,4-b]indol- 1-ones have been designed, synthesized, and evaluated as RET protein kinase inhibitors on the basis of their structural similarity with the prototype indolin-2-one RPI-1. Some β-carbolin-2-ones (structure 2) showed an ability to inhibit RET enzymatic activity in vitro and proliferation of RETC634R oncogene-transformed NIH3T3 cells comparable to that of the reference compound. The docking analysis of the interaction of these compounds with the crystallographic structure of RET tyrosine kinase domain suggested a new binding interaction scheme different from the one proposed during their design. The rigid structure of the compounds of this series represents a new scaffold with potential advantages in the design of RET protein kinase inhibitors.