109296-32-4

Upstream product

• 131149-78-5 2-(N-benzyl)amino-4-chloro-3,3-dimethylbutanenitrile 
• 135679-54-8 2-(N-methyl)amino-4-chloro-3,3-dimethylbutanenitrile 
• 106367-20-8 Benzyl-[3-chloro-2,2-dimethyl-prop-(E)-ylidene]-amine 
• 99315-22-7 N-(3-chloro-2,2-dimethylpropylidene)-1-phenylmethanamine 

Relevant academic research and scientific papers

Synthesis of 1-amino-2,2-dialkylcyclopropanecarboxylic acids from β-chloroaldimines

A variety of hydrogen cyanide adducts of β-chloroaldimines using acetone cyanohydrin were prepared. The reactive behaviour of these α-amino-γ-chloronitriles towards bases was investigated with the aim to generate 1-aminocyclopropanecarbonitriles, which ar

Synthesis of 2,2-dialkylcyclopropylamines from β-chloroimines and application towards the synthesis of 1-amino-2,2-dialkylcyclopropane-carboxylic acids

Base-induced 1,5-dehydrochlorination of β-chloroimines, having a relatively acidic hydrogen atom at carbon-1 of the N-substituent (e.g. benzyl, methoxycarbonylmethyl, α-methylbenzyl), afforded N-cyclopropylimines which were easily hydrolyzed into cyclopropylamines. This synthetic methodology was applied to the synthesis of the potentially plant growth regulating 1-amino-2,2-dialkylcyclopropanecarboxylic acids via oxidation with catalytic ruthenium(IV)oxide/sodium periodate of suitably N-protected 1-aryl-2,2-dialkylcyclopropylamines.