1092961-64-2Relevant academic research and scientific papers
Consecutive alkene cross-metathesis/oxonium ylide formation - Rearrangement: Synthesis of the anti-HIV agent hyperolactone C
Hodgson, David M.,Angrish, Deepshikha,Erickson, Stephanie P.,Kloesges, Johannes,Lee, Caroline H.
supporting information; experimental part, p. 5553 - 5556 (2009/06/18)
(Chemical Equation Presented) α-Diazo-β-ketoesters bearing allylic ether functionality undergo highly stereoselective Ru-carbene-catalyzed alkene cross-metathesis followed by Rh2(OAc)4-catalyzed oxonium ylide formation/[2,3] sigmatropic rearrangement in a one-flask operation and in a highly diastereoselective manner. The methodology has been demonstrated in a concise synthesis of the anti-HIV agent hyperolactone C.
