109299-79-8

Basic information

• Product Name: 2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE
• Synonyms: 2,4-Di(tert-butoxy)pyrimidin-5-ylboronic acid hydrate, May contain varying amounts of anhydride, 97%;[2,4-bis(tert-butoxy)pyriMidin-5-yl]boronic acid;2,4-Di(tert-butoxy)pyriMidin-5-ylboronic acid hydrate, 97%, Variable anhydride content
• CAS NO: 109299-79-8
• Molecular Formula: C₁₂H₂₁BN₂O₄
• Molecular Weight: 268.12
• EINECS: 220-753-0
• Mol File: 109299-79-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 431.408 °C at 760 mmHg
• Flash Point: 214.708 °C
• Appearance: /
• Density: 1.134 g/cm³
• Vapor Pressure: 3.29E-08mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE(109299-79-8)
• EPA Substance Registry System: 2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE(109299-79-8)

Safety Data

• Hazardous Substances Data: 109299-79-8(Hazardous Substances Data)

Usage

Description

2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE is a chemical compound that serves as a versatile reagent in the synthesis of flexible nucleosides. These nucleosides have the potential to be developed into effective anticancer and antiviral drugs due to their unique structural properties and ability to target specific biological processes.

Uses

Used in Pharmaceutical Industry:
2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE is used as a synthetic reagent for the development of flexible nucleosides, which are crucial in creating potential anticancer and antiviral drugs. Its role in the synthesis process is to facilitate the formation of these nucleosides, which can then be further studied and optimized for their therapeutic potential.
In the development of anticancer drugs, 2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE aids in the creation of nucleoside analogs that can target and inhibit the replication of cancer cells, thereby contributing to the fight against various types of cancer.
In the context of antiviral drug development, this reagent is instrumental in synthesizing nucleoside analogs that can interfere with the replication and life cycle of viruses, providing a means to combat viral infections and their associated diseases.
Overall, 2,4-DI(TERT-BUTOXY)PYRIMIDIN-5-YLBORONIC ACID HYDRATE plays a significant role in the pharmaceutical industry as a key component in the synthesis of nucleosides with potential applications in cancer and viral treatment.

InChI:InChI=1/C12H21BN2O4/c1-11(2,3)18-9-8(13(16)17)7-14-10(15-9)19-12(4,5)6/h7,16-17H,1-6H3

Upstream product

• 19752-61-5 5-bromo-2,4-di(tert-butoxy)pyrimidine 

Downstream Products

• 132400-59-0 2,4-di-tert-butoxy-5-(3-methyl-thiophen-2-yl)-pyrimidine 
• 127235-84-1 2,4-di-tert-butoxy-5-(pyridin-2-yl)pyrimidine 
• 127236-15-1 2,4-Di-tert-butoxy-5-pyridin-3-yl-pyrimidine 
• 127236-16-2 2,4-Di-tert-butoxy-5-pyridin-4-yl-pyrimidine 
• 132400-61-4 5-trans-propenyl-2,4-di-t-butoxypyrimidine 
• 178411-13-7 2,4-di-t-butoxy-5-(3'-iodophenyl)pyrimidine 
• 1245898-50-3 5-(3-bromo-5-tert-butyl-4-methoxyphenyl)-2,4-di-tert-butoxypyrimidine 
• 1245898-39-8 N-(6-(3-tert-butyl-5-(2,4-di-tert-butoxypyrimidin-5-yl)-4-methoxyphenyl)naphthalen-2-yl)methanesulfonamide 
• 1245899-21-1 2,4-di-tert-butoxy-5-(3-tert-butyl-5-iodo-4-methoxyphenyl)pyrimidine 
• 178411-11-5 2,4-di-t-butoxy-5-(3'-aminophenyl)pyrimidine 
• 7306-78-7 2,4-di-tert-butoxy-pyrimidine 
• 132400-58-9 2,4-Di-tert-butoxy-5-(3-hexyl-thiophen-2-yl)-pyrimidine 

Relevant articles and documents

Synthesis of 5-fluorovinyl derivatives of pyrimidines via Suzuki-Miyaura coupling and their 1,3-dipolar cycloaddition reactions with nitrones

A simple two-step synthesis of a new class of fluorinated isoxazolidinyl derivatives of pyrimidine is described. The reactions proceed via the Suzuki-Miyaura coupling followed by highly regioselective 1,3-dipolar cycloaddition with nitrones. Removal of th