109306-10-7

Basic information

• Product Name: 3-(2-methylphenoxy)-3-phenylpropan-1-amine
• Synonyms: Benzenepropanamine, gamma-(2-methylphenoxy)-
• CAS NO: 109306-10-7
• Molecular Formula: C₁₆H₁₉NO
• Molecular Weight: 241.3282
• Mol File: 109306-10-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 379.2°C at 760 mmHg
• Flash Point: 181.3°C
• Density: 1.059g/cm³
• Vapor Pressure: 5.94E-06mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 3-(2-methylphenoxy)-3-phenylpropan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methylphenoxy)-3-phenylpropan-1-amine(109306-10-7)
• EPA Substance Registry System: 3-(2-methylphenoxy)-3-phenylpropan-1-amine(109306-10-7)

Safety Data

• Hazardous Substances Data: 109306-10-7(Hazardous Substances Data)

Upstream product

• 5053-63-4 3-amino-1-phenylpropan-1-ol 
• 62872-58-6 3-iodo-1-phenyl-propan-1-ol 
• 745716-86-3 3-chloro-3-phenylpropylamine 
• 95-48-7 ortho-cresol 

Downstream Products

• 1250437-79-6 9,10-dihydro-N-[3-(2-methylphenoxy)-3-phenylpropyl]-9-oxoacridine-4-carboxamide 

Relevant articles and documents

Design, synthesis and evaluation of substituted N-(3-arylpropyl)-9,10- dihydro-9-oxoacridine-4-carboxamides as potent MDR reversal agents in cancer

A novel class of molecules with structure N-(3-arylpropyl)-9,10-dihydro-9- oxoacridine-4-carboxamides (20-29) were designed by generating a pharmacophore for potent MDR reversal activity using phase drug design software. The designed molecules were synthesized by a novel synthesis route and evaluated for their inhibitory effects on the transport activity of P-glycoprotein (P-gp) by standard Hoechst 33342 assay method. Based on the pIC50 values of ten title compounds screened, three compounds exhibited better activity as compared to Verapamil used as standard.