1093095-07-8

Basic information

• Product Name: C₁₂H₁₆N₂O₂
• Synonyms: C₁₂H₁₆N₂O₂
• CAS NO: 1093095-07-8
• Molecular Weight: 220.271
• Mol File: 1093095-07-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₆N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₆N₂O₂(1093095-07-8)
• EPA Substance Registry System: C₁₂H₁₆N₂O₂(1093095-07-8)

Safety Data

• Hazardous Substances Data: 1093095-07-8(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 110-52-1 1,4-dibromo-butane 
• 4187-53-5 (S)-1-(p-nitrophenyl)ethylamine 

Relevant articles and documents

Secondary amines as coupling partners in direct catalytic asymmetric reductive amination

The secondary amine participating asymmetric reductive amination remains an unsolved problem in organic synthesis. Here we show for the first time that secondary amines are capable of effectively serving as N-sources in direct asymmetric reductive amination to afford corresponding tertiary chiral amines with the help of a selected additive set under mild conditions (0-25 °C). The applied chiral phosphoramidite ligands are readily prepared from BINOL and easily modified. Compared with common tertiary chiral amine synthetic methods, this procedure is much more concise and scalable, as exemplified by the facile synthesis of rivastigmine and N-methyl-1-phenylethanamine.