1093095-07-8Relevant academic research and scientific papers
Secondary amines as coupling partners in direct catalytic asymmetric reductive amination
Wu, Zitong,Du, Shaozhi,Gao, Guorui,Yang, Wenkun,Yang, Xiongyu,Huang, Haizhou,Chang, Mingxin
, p. 4509 - 4514 (2019/04/29)
The secondary amine participating asymmetric reductive amination remains an unsolved problem in organic synthesis. Here we show for the first time that secondary amines are capable of effectively serving as N-sources in direct asymmetric reductive amination to afford corresponding tertiary chiral amines with the help of a selected additive set under mild conditions (0-25 °C). The applied chiral phosphoramidite ligands are readily prepared from BINOL and easily modified. Compared with common tertiary chiral amine synthetic methods, this procedure is much more concise and scalable, as exemplified by the facile synthesis of rivastigmine and N-methyl-1-phenylethanamine.
INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER
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Page/Page column 27, (2009/01/24)
The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
