1093101-68-8

Basic information

• Product Name: (R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine
• Synonyms: (R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine
• CAS NO: 1093101-68-8
• Molecular Weight: 341.797
• Mol File: 1093101-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine(1093101-68-8)
• EPA Substance Registry System: (R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine(1093101-68-8)

Safety Data

• Hazardous Substances Data: 1093101-68-8(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 42398-73-2 6-methylisoquinoline 
• 188121-31-5 6-methyl-5-nitroisoquinoline 
• 943606-84-6 1-chloro-6-methyl-5-nitroisoquinoline 
• 27298-99-3 (R)-1-(4-chlorophenyl)ethylamine 
• 943606-83-5 6-methyl-5-nitroisoquinoline N-oxide 

Downstream Products

• 1093101-69-9 (R)-N₁-(1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine 
• 1093100-63-0 N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine 
• 1093101-70-2 N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine 

Relevant articles and documents

RAF KINASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the activity of Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula (I) wherein each of A1, A2, A3, A4, A5, A6, A7, A8, A9, bond B, X, rings Z1 and Z2, R1 and R3 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.