1093255-30-1

Basic information

• Product Name: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide
• Synonyms: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide
• CAS NO: 1093255-30-1
• Molecular Weight: 647.536
• Mol File: 1093255-30-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide(1093255-30-1)
• EPA Substance Registry System: N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-(triphenylmethyl)-1H-imidazole-4-carboxamide(1093255-30-1)

Safety Data

• Hazardous Substances Data: 1093255-30-1(Hazardous Substances Data)

Upstream product

• 1093260-81-1 3-chloro-5-({6-chloro-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile 
• 473923-96-5 3-chloro-5-methoxybenzonitrile 
• 771-69-7 2,3,4-trifluoronitrobenzene 
• 1093254-29-5 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile 
• 191103-80-7 1H-1-triphenylmethylimidazole-4-carboxylic acid 
• 1089178-83-5 3-{[3-(bromomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile 
• 1089178-82-4 3-chloro-5-[(6-chloro-2-fluoro-3-methylphenyl)oxy]benzonitrile 
• 1093260-77-5 3-[(6-amino-2-fluoro-3-methylphenyl)oxy]-5-chlorobenzonitrile 
• 1093260-75-3 3-chloro-5-[(2-fluoro-3-methyl-6-nitrophenyl)oxy]benzonitrile 
• 1093260-71-9 bis(1,1-dimethylethyl) {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate 
• 76-83-5 trityl chloride 

Downstream Products

• 1093255-32-3 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-4-carboxamide trifluoroacetate 

Relevant articles and documents

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ray crystallography of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively to help identify and optimize the key hydrogen-bonding motif. This led directly to the design of compound 43 that exhibits remarkable antiviral activity (EC50 1 nM) against a wide range of NNRTI-resistant viruses and a favorable pharmacokinetic profile across multiple species.