1093282-99-5Relevant academic research and scientific papers
Zwitterionic liquid (ZIL) coated CuO as an efficient catalyst for the green synthesis of bis-coumarin derivatives: via one-pot multi-component reactions using mechanochemistry
Mayank,Singh, Amanpreet,Raj, Pushap,Kaur, Randeep,Singh, Ajnesh,Kaur, Navneet,Singh, Narinder
, p. 3872 - 3881 (2017)
A convenient, solvent free strategy for the synthesis of bis-coumarins has been developed using zwitterionic liquid (ZIL) coated copper oxide (CuO) and mechanical ball milling. The ZIL were fabricated from imidazolium/benzimidazolium and sulfonate/carboxy
Bis-coumarins; non-cytotoxic selective urease inhibitors and antiglycation agents
Salar, Uzma,Nizamani, Arsalan,Arshad, Fizza,Khan, Khalid Mohammed,Fakhri, Muhammed Imran,Perveen, Shahnaz,Ahmed, Nessar,Choudhary, M. Iqbal
, (2019/08/12)
The current study is concerned with the identification of lead molecules based on the bis-coumarin scaffold having selective urease inhibitory and antiglycation activities. For that purpose, bis-coumarins (1-44) were synthesized and structurally characterized by different spectroscopic techniques. Eight derivatives 4, 8-10, 14, 17, 34, and 40 demonstrated urease inhibition in the range of IC50 = 4.4 ± 0.21–115.6 ± 2.13 μM, as compared to standard thiourea (IC50 = 21.3 ± 1.3 μM). Especially, compound 17 (IC50 = 4.4 ± 0.21 μM) was found to be five-fold more potent than the standard. Kinetic studies were also performed on compound 17 in order to identify the mechanism of inhibition. Kinetic studies revealed that compound 17 is a competitive inhibitor. Antiglycation activity was evaluated using glycation of bovine serum albumin by methylglyoxal in vitro. Compounds 2, 11-13, 16, 17, 19–22, 35, 37, and 42 showed good to moderate antiglycation activities with IC50 values of 333.63–919.72 μM, as compared to the standard rutin (IC50 = 294.46 ± 1.5 μM). Results of both assays showed that the compounds with urease inhibitory activity did not show any antiglycation potential, and vice versa. Only compound 17 showed dual inhibition potential. All compounds were also evaluated for cytotoxicity. Compounds 17, 19, and 37 showed a weak toxicity towards 3 T3 mouse fibroblast cell line. All other compounds were found to be non-cytotoxic. Urease inhibition is an approach to treat infections caused by ureolytic bacteria whereas inhibition of glycation of proteins is a strategy to avoid late diabetic complications. Therefore, these compounds may serve as leads for further research.
Synthesis, structure, antimicrobial and antioxidant investigations of dicoumarol and related compounds
Hamdi, Naceur,Puerta, M. Carmen,Valerga, Pedro
, p. 2541 - 2548 (2008/12/23)
Different substituted 3,3′-arylidenebis-4-hydroxycoumarins (1-7) and tetrakis-4-hydroxycoumarin derivative 8 are the final products when 4-hydroxycoumarin and aromatic aldehydes containing different groups in ortho, meta or para positions condense in boil
