1093347-31-9Relevant academic research and scientific papers
(2-Pyridyl)phenyl methanol: A new reagent for metal-free reduction of nitro aromatic compounds
Giomi, Donatella,Alfini, Renzo,Brandi, Alberto
experimental part, p. 167 - 172 (2011/02/27)
As previously reported for 1-(2-pyridyl)-2-propen-1-ol, (2-pyridyl)phenyl methanol is able to react as hydrogen donor towards nitro aromatic and heteroaromatic compounds. Operating in the presence of methyl acrylate as an aza-Michael acceptor, a domino process involving reduction and conjugate addition steps allows the one pot formation of β-amino esters. The crucial role of the pyridine nucleus in making this purely thermal reactivity of carbinols possible has been shown.
New reactivity of 1-(2-pyridyl)-2-propen-1-ol with nitro derivatives
Giomi, Donatella,Alfini, Renzo,Brandi, Alberto
scheme or table, p. 6977 - 6979 (2009/04/07)
1-(2-Pyridyl)-2-propen-1-ol showed an unprecedented reactivity behaving as Hantzsch ester 1,4-dihydropyridine mimic for the metal-free reduction of the nitro group of electron-deficient aromatic and heteroaromatic nitro compounds to the corresponding amino function. The redox mechanism is part of a domino process involving a direct trapping of the amino derivatives through aza-Michael addition to the vinyl ketone intermediate leading to the one-pot formation of new functionalised aminoacylpyridines.
