31796-72-2

Basic information

• Product Name: (S)-(+)-α-phenyl-2-pyridylmethanol
• Synonyms: (S)-(+)-α-phenyl-2-pyridylmethanol
• CAS NO: 31796-72-2
• Molecular Weight: 185.225
• Mol File: 31796-72-2.mol
• Article Data: 133

Chemical Properties

• CAS DataBase Reference: (S)-(+)-α-phenyl-2-pyridylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-α-phenyl-2-pyridylmethanol(31796-72-2)
• EPA Substance Registry System: (S)-(+)-α-phenyl-2-pyridylmethanol(31796-72-2)

Safety Data

• Hazardous Substances Data: 31796-72-2(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 100-52-7 benzaldehyde 
• 1121-60-4 pyridine-2-carbaldehyde 
• 101-82-6 2-Benzylpyridine 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 108-00-9 N,N-dimethylethylenediamine 
• 33240-34-5 cyclopentylmagnesium bromide 
• 21970-13-8 (pyridin-2-yl)magnesium bromide 
• 109-04-6 2-bromo-pyridine 
• 5029-67-4 2-iodopyridine 
• 7677-24-9 trimethylsilyl cyanide 
• 74-86-2 acetylene 
• 13737-04-7 2-(trimethylsilyl)pyridine 
• 21948-75-4 2-methylsulfinylpyridine 

Downstream Products

• 5583-33-5 (R)-(-)-α-phenyl-2-pyridylmethanol 
• 5583-33-5 (S)-(+)-α-phenyl-2-pyridylmethanol 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 3678-70-4 Diphenyl-2-pyridylmethan 
• 77744-14-0 1-Phenyl-1-(2-pyridyl)-2-propen-1-ol 

Relevant articles and documents

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Green synthesis method of polyaryl substituted methanol

The invention relates to a green synthesis method of polyaryl substituted methanol, in particular to a method for efficiently synthesizing polyaryl substituted methanol in a polar aprotic solvent under the condition of an oxidizing agent by taking polyaryl substituted methane as a raw material and alkali as an additive. The method provided by the invention is green and environment-friendly, avoids using expensive metal catalysts, and has the advantages of low cost, few reaction steps, short time, high yield and the like.

Asymmetric reduction of aromatic heterocyclic ketones with bio-based catalyst Lactobacillus kefiri P2

Abstract: Chiral heterocyclic secondary alcohols have received much attention due to their widespread use in pharmaceutical intermediates. In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asymmetric reduction of prochiral ketones to chiral secondary alcohols. Secondary chiral carbinols were obtained by asymmetric bioreduction of different prochiral substrates with results up to > 99% enantiomeric excess (ee). (R)-1-(benzofuran-2-yl)ethanol 5a, which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective β-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70?g of (R)-5a in enantiomerically pure form was obtained in 96% yield. Also, production of (R)-5a in terms of yield and gram scale through catalytic asymmetric reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcohols compared to chemical processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis. Graphical Abstract: [Figure not available: see fulltext.]

Nitrous oxide as a diazo transfer reagent: The synthesis of triazolopyridines

Nitrous oxide is a potential diazo transfer reagent, but its applications in organic chemistry are scarce. Here, we show that triazolopyridines and triazoloquinolines are formed in the reactions of metallated 2-alkylpyridines or 2-alkylquinolines with N2O. The reactions can be performed under mild conditions and give synthetically interesting triazoles in moderate to good yields.