109337-60-2Relevant academic research and scientific papers
Deuterated Aryl Alkyl Ethers Synthesis via Nucleophilic Etherification of Aryl Alkyl Ethers and Thioethers with Deuterated Alcohols
Li, Shuai,Wang, Xia,Wang, Xue-Qiang,Yang, Xin-Ge,Yu, Gui-Quan
, p. 1805 - 1809 (2019)
A transition-metal-free etherification protocol that is capable of synthesizing deuterated ethers is described. A wide range of aryl alkyl ethers and thioethers were suitable for this transformation owing to the mild reaction conditions. Besides, a series of sterically bulky deuterated alcohols were successfully incorporated into cyano-substituted arenes. The results of mechanistic studies suggested this reaction might take place via nucleophilic aromatic substitution pathway.
Improved Process for the Palladium-Catalyzed C-O Cross-Coupling of Secondary Alcohols
Zhang, Hong,Ruiz-Castillo, Paula,Schuppe, Alexander W.,Buchwald, Stephen L.
, p. 5369 - 5374 (2020)
An improved protocol for the Pd-catalyzed C-O cross-coupling of secondary alcohols is described. The use of biaryl phosphine L2 as the ligand was key to achieving efficient cross-coupling of (hetero)aryl chlorides with only a 20percent molar excess of the alcohol. Additionally, we observed an unusual reactivity difference between an electron-rich aryl bromide and the analogous aryl chloride, and deuterium-labeling suggested that currently unidentified pathways for reduction play an important role in explaining this disparity.
OXIDATION OF N-ALKYL-N'-TOSYLHYDRAZINES WITH Hg(OAc)2. A NEW SYNTHESIS OF ETHERS
Gasparrini, F.,Caglioti, L.,Misiti, D.,Palmieri, G.,Ballini,R.
, p. 3609 - 3613 (2007/10/02)
N-Alkyl-N'-tosylhydrazines with Hg(OAc)2 in the presence of alcohols or phenol give high yields of corresponding ethers.Reactions in the presence of acetic acid are also examined.
