1093392-55-2Relevant academic research and scientific papers
COMPOUNDS AND COMPOSITIONS FOR LABELING LIPID DROPLETS, AND A METHOD FOR VISUALIZATION OF CELLS AND/OR CELLULAR ORGANELLES
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Page/Page column 15-16, (2009/01/23)
The present patent relates to lipid droplet labeling compounds, having the general structure shown in formula I, (I) wherein X are each independently hydrogen, halogen, -C1-20-alkyl, -C2-20-alkenyl, -C2-20-alkinyl, -C5-6-cykloalkyl, aryl, aralkyl, adamantyl, heterocyclic, hydroxyl, hydroxyalkyl, Or -N-(R1, R2) group; n is 0, 1, 2, 3, or 4; R1 and R2 may each be independently hydrogen, straight or branching alkyl, cyclo-alkyl, aryl, aralkyl, heterocyclic group, wherein each is un-substituted or halogen substituted; or R1 and R2 together with the nitrogen in between them form a 5 or 6 member ring; A is a single bond, -O-, -S-, -CH2-, or -NH-; Y is O or S; Z is O or S; R' and R are each independently methyl, ethyl, isopropyl, isobuthyl, sec- butyl or terc-butyl. The patent also pertains to lipid droplet labeling compositions, which contain formula I and other additives or carriers. The invention further relates to a method for visualizing cells and/ or organelles with a fluorescent imaging technique, the method comprising: - labeling the cells and/ or organelles with one or more fluorescent compounds preferably being in the form of a solution, and - irradiating the cells and/or organelles with light of appropriate wavelength. The method is characterized by providing one or more fluorescent compounds having formula I for labeling the cells and/or organelles.
