1093435-75-6Relevant academic research and scientific papers
Asymmetric β,γ′-regioselective [4 + 3] and [4 + 2] annulations of α-vinylenals: Via cascade iminium ion-dienamine catalysis
Gao, Yang,Song, Xue,Yan, Ru-Jie,Du, Wei,Chen, Ying-Chun
, p. 151 - 155 (2021/01/14)
Introduction of an α-vinyl group into enal substrates can prohibit the traditional [3 + 2] cycloaddition with N-2,2,2-trifluoroethyl isatin imines catalysed by a chiral secondary amine, but give β,γ′-regioselective [4 + 3] annulation products via cascade iminium ion-dienamine catalysis. A spectrum of CF3-containing spirooxindoles incorporating an azepane motif were constructed with good to excellent enantioselectivities. In addition, asymmetric [4 + 2] annulations between α-vinylenals and α,α-dicyanoalkenes were disclosed through a similar catalytic strategy, generally affording complex tricyclic frameworks with outstanding enantioselectivities.
Synthesis of γ-alkylidene α,β-unsaturated δ-lactones by ring-closing metathesis: Application to the synthesis of the C 1-C8 subunit of Biselide E
Salit, Anne-Frédérique,Barbazanges, Marion,Miege, Frédéric,Larrauf?e, Marie-Hélène,Meyer, Christophe,Cossy, Janine
scheme or table, p. 2583 - 2586 (2009/04/16)
The synthesis of γ-alkylidene α,β-unsaturated δ-lactones was achieved by ring-closing metathesis of acrylates derived from (1,3-butadien-2-y1)methanols. The application to the synthesis of the C1-C8 subunit of biselide E is reported.
