109347-43-5 Usage
Uses
Used in Organic Synthesis:
4-iodophenylacetaldehyde is utilized as a building block in organic synthesis, contributing to the creation of complex organic molecules and compounds. Its reactivity and aromatic nature make it a valuable component in the synthesis process.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-iodophenylacetaldehyde is employed as a key intermediate in the development of new drugs. Its unique chemical properties allow for the exploration of its potential in the synthesis of biologically active molecules.
Used in Perfumery:
4-iodophenylacetaldehyde is used as a fragrance ingredient in the production of various perfumes. Its distinctive smell and aromatic properties make it a desirable component in creating unique and appealing scents.
Used in Flavor Industry:
4-iodophenylacetaldehyde is also utilized in the flavor industry, where it contributes to the development of flavors for food and beverages. Its aromatic nature allows for the creation of flavors with a unique taste profile.
Used in Aromatic Compounds Production:
4-iodophenylacetaldehyde is employed in the production of other aromatic compounds, which are used in various applications such as cosmetics, detergents, and air fresheners.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-iodophenylacetaldehyde has potential applications as a precursor for the synthesis of pharmaceutical drugs. Its ability to serve as a starting material for the development of new medications highlights its importance in drug discovery and innovation.
Check Digit Verification of cas no
The CAS Registry Mumber 109347-43-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,4 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 109347-43:
(8*1)+(7*0)+(6*9)+(5*3)+(4*4)+(3*7)+(2*4)+(1*3)=125
125 % 10 = 5
So 109347-43-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H7IO/c9-8-3-1-7(2-4-8)5-6-10/h1-4,6H,5H2
109347-43-5Relevant academic research and scientific papers
Selective N1/N4 1,4-Cycloaddition of 1,2,4,5-Tetrazines Enabled by Solvent Hydrogen Bonding
Zhu, Zixi,Glinkerman, Christopher M.,Boger, Dale L.
supporting information, p. 20778 - 20787 (2020/12/22)
An unprecedented 1,4-cycloaddition (vs 3,6-cycloaddition) of 1,2,4,5-tetrazines is described with preformed or in situ generated aryl-conjugated enamines promoted by the solvent hydrogen bonding of hexafluoroisopropanol (HFIP) that is conducted under mild reaction conditions (0.1 M HFIP, 25 °C, 12 h). The reaction constitutes a formal [4 + 2] cycloaddition across the two nitrogen atoms (N1/N4) of the 1,2,4,5-tetrazine followed by a formal retro [4 + 2] cycloaddition loss of a nitrile and aromatization to generate a 1,2,4-triazine derivative. The factors that impact the remarkable change in the reaction mode, optimization of reaction parameters, the scope and simplification of its implementation through in situ enamine generation from aldehydes and ketones, the reaction scope for 3,6-bis(thiomethyl)-1,2,4,5-tetrazine, a survey of participating 1,2,4,5-tetrazines, and key mechanistic insights into this reaction are detailed. Given its simplicity and breath, the study establishes a novel method for the simple and efficient one-step synthesis of 1,2,4-triazines under mild conditions from readily accessible starting materials. Whereas alternative protic solvents (e.g., MeOH vs HFIP) provide products of the conventional 3,6-cycoladdition, the enhanced hydrogen bonding capability of HFIP uniquely results in promotion of the unprecedented formal 1,4-cycloaddition. As such, the studies represent an example of not just an enhancement in the rate or efficiency of a heterocyclic azadiene cycloaddition by hydrogen bonding catalysis but also the first to alter the mode (N1/N4 vs C3/C6) of cycloaddition.
